Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control

Caroline Fluur, Bence Rethi, Pham Hong Thang, Nancy Vivar, Frida Mowafi, Lucia Lopalco, Caterina Uberti Foppa, Anders Karlsson, Giuseppe Tambussi, Francesca Chiodi

Research output: Contribution to journalArticle

Abstract

Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P <0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.

Original languageEnglish
Pages (from-to)1048-1050
Number of pages3
JournalAIDS (London, England)
Volume21
Issue number8
DOIs
Publication statusPublished - May 2007

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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