Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control

Caroline Fluur; Bence Rethi; Pham Hong Thang; Nancy Vivar; Frida Mowafi; Lucia Lopalco; Caterina Uberti Foppa; Anders Karlsson; Giuseppe Tambussi; Francesca Chiodi

doi:10.1097/QAD.0b013e32810c8caa

Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control

Caroline Fluur, Bence Rethi, Pham Hong Thang, Nancy Vivar, Frida Mowafi, Lucia Lopalco, Caterina Uberti Foppa, Anders Karlsson, Giuseppe Tambussi, Francesca Chiodi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P <0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.

Original language	English
Pages (from-to)	1048-1050
Number of pages	3
Journal	AIDS (London, England)
Volume	21
Issue number	8
DOIs	https://doi.org/10.1097/QAD.0b013e32810c8caa
Publication status	Published - May 2007

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ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

Fluur, C., Rethi, B., Thang, P. H., Vivar, N., Mowafi, F., Lopalco, L., Foppa, C. U., Karlsson, A., Tambussi, G., & Chiodi, F. (2007). Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control. AIDS (London, England), 21(8), 1048-1050. https://doi.org/10.1097/QAD.0b013e32810c8caa

Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control. / Fluur, Caroline; Rethi, Bence; Thang, Pham Hong; Vivar, Nancy; Mowafi, Frida; Lopalco, Lucia ; Foppa, Caterina Uberti; Karlsson, Anders; Tambussi, Giuseppe; Chiodi, Francesca.

In: AIDS (London, England), Vol. 21, No. 8, 05.2007, p. 1048-1050.

Research output: Contribution to journal › Article

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10.1097/QAD.0b013e32810c8caa