Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction

Giampaolo Niccoli, Alberto Menozzi, Davide Capodanno, Carlo Trani, Vasile Sirbu, Massimo Fineschi, Chiara Zara, Filippo Crea, Daniela Trabattoni, Francesco Saia, Elena Ladich, Giuseppe Biondi-Zoccai, Guilherme F. Attizzani, Giulio Guagliumi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To compare angiographic and optical coherence tomography (OCT) data pertinent to thrombi, along with the histologic characteristics of aspirated thrombi in patients presenting with ST elevation myocardial infarction (STEMI) with or without inflammation, as assessed by C-reactive protein (CRP) and myeloperoxidase (MPO).

METHODS: In the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty) study, 140 patients with STEMI referred for primary percutaneous intervention were enrolled. The patients underwent OCT assessment of the culprit vessel, along with blood sampling of CRP and MPO, and histologic analysis of the thrombus.

RESULTS: Biomarkers were available for 129 patients, and histology and immunohistochemistry of the thrombi were available for 78 patients. Comparisons were made using the median thresholds of CRP and MPO (2.08 mg/L and 604.124 ng/mL, respectively). There was no correlation between CRP and MPO levels in the whole population (p = 0.685). Patients with high CRP levels had higher thrombus grades and more frequent TIMI flow 0/1 compared with those with low CRP levels (5 [1st quartile 3; 3rd quartile 5] vs. 3.5 mg/L [1; 5], p = 0.007, and 69.3 vs. 48.5%, p = 0.04, respectively). Patients with high MPO levels more commonly had early thrombi than had those with low MPO levels (42.5 vs. 20.0%, p = 0.04).

CONCLUSIONS: CRP and MPO were not correlated in STEMI patients, possibly reflecting different pathogenic mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalCardiology
Volume137
Issue number1
DOIs
Publication statusE-pub ahead of print - Dec 17 2016

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C-Reactive Protein
Peroxidase
Thrombosis
Biomarkers
Serum
Optical Coherence Tomography
ST Elevation Myocardial Infarction
Angioplasty
Histology
Immunohistochemistry
Inflammation
Population

Keywords

  • Journal Article

Cite this

Niccoli, G., Menozzi, A., Capodanno, D., Trani, C., Sirbu, V., Fineschi, M., ... Guagliumi, G. (2016). Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction. Cardiology, 137(1), 27-35. https://doi.org/10.1159/000452705

Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction. / Niccoli, Giampaolo; Menozzi, Alberto; Capodanno, Davide; Trani, Carlo; Sirbu, Vasile; Fineschi, Massimo; Zara, Chiara; Crea, Filippo; Trabattoni, Daniela; Saia, Francesco; Ladich, Elena; Biondi-Zoccai, Giuseppe; Attizzani, Guilherme F.; Guagliumi, Giulio.

In: Cardiology, Vol. 137, No. 1, 17.12.2016, p. 27-35.

Research output: Contribution to journalArticle

Niccoli, G, Menozzi, A, Capodanno, D, Trani, C, Sirbu, V, Fineschi, M, Zara, C, Crea, F, Trabattoni, D, Saia, F, Ladich, E, Biondi-Zoccai, G, Attizzani, GF & Guagliumi, G 2016, 'Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction', Cardiology, vol. 137, no. 1, pp. 27-35. https://doi.org/10.1159/000452705
Niccoli, Giampaolo ; Menozzi, Alberto ; Capodanno, Davide ; Trani, Carlo ; Sirbu, Vasile ; Fineschi, Massimo ; Zara, Chiara ; Crea, Filippo ; Trabattoni, Daniela ; Saia, Francesco ; Ladich, Elena ; Biondi-Zoccai, Giuseppe ; Attizzani, Guilherme F. ; Guagliumi, Giulio. / Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction. In: Cardiology. 2016 ; Vol. 137, No. 1. pp. 27-35.
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abstract = "OBJECTIVES: To compare angiographic and optical coherence tomography (OCT) data pertinent to thrombi, along with the histologic characteristics of aspirated thrombi in patients presenting with ST elevation myocardial infarction (STEMI) with or without inflammation, as assessed by C-reactive protein (CRP) and myeloperoxidase (MPO).METHODS: In the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty) study, 140 patients with STEMI referred for primary percutaneous intervention were enrolled. The patients underwent OCT assessment of the culprit vessel, along with blood sampling of CRP and MPO, and histologic analysis of the thrombus.RESULTS: Biomarkers were available for 129 patients, and histology and immunohistochemistry of the thrombi were available for 78 patients. Comparisons were made using the median thresholds of CRP and MPO (2.08 mg/L and 604.124 ng/mL, respectively). There was no correlation between CRP and MPO levels in the whole population (p = 0.685). Patients with high CRP levels had higher thrombus grades and more frequent TIMI flow 0/1 compared with those with low CRP levels (5 [1st quartile 3; 3rd quartile 5] vs. 3.5 mg/L [1; 5], p = 0.007, and 69.3 vs. 48.5{\%}, p = 0.04, respectively). Patients with high MPO levels more commonly had early thrombi than had those with low MPO levels (42.5 vs. 20.0{\%}, p = 0.04).CONCLUSIONS: CRP and MPO were not correlated in STEMI patients, possibly reflecting different pathogenic mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.",
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T1 - Relationship between Serum Inflammatory Biomarkers and Thrombus Characteristics in Patients with ST Segment Elevation Myocardial Infarction

AU - Niccoli, Giampaolo

AU - Menozzi, Alberto

AU - Capodanno, Davide

AU - Trani, Carlo

AU - Sirbu, Vasile

AU - Fineschi, Massimo

AU - Zara, Chiara

AU - Crea, Filippo

AU - Trabattoni, Daniela

AU - Saia, Francesco

AU - Ladich, Elena

AU - Biondi-Zoccai, Giuseppe

AU - Attizzani, Guilherme F.

AU - Guagliumi, Giulio

N1 - © 2016 S. Karger AG, Basel.

PY - 2016/12/17

Y1 - 2016/12/17

N2 - OBJECTIVES: To compare angiographic and optical coherence tomography (OCT) data pertinent to thrombi, along with the histologic characteristics of aspirated thrombi in patients presenting with ST elevation myocardial infarction (STEMI) with or without inflammation, as assessed by C-reactive protein (CRP) and myeloperoxidase (MPO).METHODS: In the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty) study, 140 patients with STEMI referred for primary percutaneous intervention were enrolled. The patients underwent OCT assessment of the culprit vessel, along with blood sampling of CRP and MPO, and histologic analysis of the thrombus.RESULTS: Biomarkers were available for 129 patients, and histology and immunohistochemistry of the thrombi were available for 78 patients. Comparisons were made using the median thresholds of CRP and MPO (2.08 mg/L and 604.124 ng/mL, respectively). There was no correlation between CRP and MPO levels in the whole population (p = 0.685). Patients with high CRP levels had higher thrombus grades and more frequent TIMI flow 0/1 compared with those with low CRP levels (5 [1st quartile 3; 3rd quartile 5] vs. 3.5 mg/L [1; 5], p = 0.007, and 69.3 vs. 48.5%, p = 0.04, respectively). Patients with high MPO levels more commonly had early thrombi than had those with low MPO levels (42.5 vs. 20.0%, p = 0.04).CONCLUSIONS: CRP and MPO were not correlated in STEMI patients, possibly reflecting different pathogenic mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.

AB - OBJECTIVES: To compare angiographic and optical coherence tomography (OCT) data pertinent to thrombi, along with the histologic characteristics of aspirated thrombi in patients presenting with ST elevation myocardial infarction (STEMI) with or without inflammation, as assessed by C-reactive protein (CRP) and myeloperoxidase (MPO).METHODS: In the OCTAVIA (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty) study, 140 patients with STEMI referred for primary percutaneous intervention were enrolled. The patients underwent OCT assessment of the culprit vessel, along with blood sampling of CRP and MPO, and histologic analysis of the thrombus.RESULTS: Biomarkers were available for 129 patients, and histology and immunohistochemistry of the thrombi were available for 78 patients. Comparisons were made using the median thresholds of CRP and MPO (2.08 mg/L and 604.124 ng/mL, respectively). There was no correlation between CRP and MPO levels in the whole population (p = 0.685). Patients with high CRP levels had higher thrombus grades and more frequent TIMI flow 0/1 compared with those with low CRP levels (5 [1st quartile 3; 3rd quartile 5] vs. 3.5 mg/L [1; 5], p = 0.007, and 69.3 vs. 48.5%, p = 0.04, respectively). Patients with high MPO levels more commonly had early thrombi than had those with low MPO levels (42.5 vs. 20.0%, p = 0.04).CONCLUSIONS: CRP and MPO were not correlated in STEMI patients, possibly reflecting different pathogenic mechanisms, with CRP more related to thrombus burden and MPO to thrombus age.

KW - Journal Article

U2 - 10.1159/000452705

DO - 10.1159/000452705

M3 - Article

VL - 137

SP - 27

EP - 35

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 1

ER -