Relationship Between Serum Uric Acid and Electrocardiographic Alterations in a Large Sample of General Population: Data From the Brisighella Heart Study

Arrigo F G Cicero, Martina Rosticci, Alessandra Reggi, Giuseppe Derosa, Angelo Parini, Elisa Grandi, Sergio D’Addato, Claudio Borghi

Research output: Contribution to journalArticle

Abstract

Introduction: Serum uric acid (SUA) may contribute to the increased cardiovascular damage through direct injury to the endothelium and alteration of cardiovascular function. Aim: To evaluate the association of SUA with the presence of the most recurrent electrographic alterations and with the length of the main ECG intervals in a large sample of general population. Methods: For this study, on the database of the Brisighella Heart Study, we evaluated the available data of 790 men and 849 women, excluding subjects affected by gout or taking antihyperuricemic agents, those taking drug increasing the QT interval and those using beta-blockers or non-dihydropyridine calcium channel blockers at the moment of the ECG registration. Multiple ascending stepwise regression analyses were carried out to determine the independent predictors of the predefined ECG alterations. Results: The prevalence of predefined ECG alterations was comparable between genders, with the exception of sinus bradicardia, left-anterior fascicular block, atrio-ventricular blocks and left ventricular hypertrophy (LVH), which appeared to be more frequent in men. The multivariate analysis revealed that SUA was associated to ischaemic alterations, LVH, sinus tachycardia and tachyarrhytmias. Age was associated to all evaluated ECG alterations beyond sinus tachycardia and LVH. Male sex was associated to sinus bradicardia, atrio-ventricular blocks, anterior-left fascicular block and LVH. Blood pressure was associated to different ECG alterations, but with clinically relevant OR with ischaemic alterations and LVH. Conclusion: SUA level is related the prevalence of both organic and rhythm ECG alterations in a wide sample of general population.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume22
Issue number2
DOIs
Publication statusPublished - Jun 11 2015

Fingerprint

Uric Acid
Electrocardiography
Left Ventricular Hypertrophy
Serum
Population
Sinus Tachycardia
Bundle-Branch Block
Gout Suppressants
Gout
Calcium Channel Blockers
Endothelium
Multivariate Analysis
Regression Analysis
Databases
Blood Pressure
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • Arrhythmias
  • Electrocardiogram
  • Epidemiology
  • Serum uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Relationship Between Serum Uric Acid and Electrocardiographic Alterations in a Large Sample of General Population : Data From the Brisighella Heart Study. / Cicero, Arrigo F G; Rosticci, Martina; Reggi, Alessandra; Derosa, Giuseppe; Parini, Angelo; Grandi, Elisa; D’Addato, Sergio; Borghi, Claudio.

In: High Blood Pressure and Cardiovascular Prevention, Vol. 22, No. 2, 11.06.2015, p. 129-134.

Research output: Contribution to journalArticle

Cicero, Arrigo F G ; Rosticci, Martina ; Reggi, Alessandra ; Derosa, Giuseppe ; Parini, Angelo ; Grandi, Elisa ; D’Addato, Sergio ; Borghi, Claudio. / Relationship Between Serum Uric Acid and Electrocardiographic Alterations in a Large Sample of General Population : Data From the Brisighella Heart Study. In: High Blood Pressure and Cardiovascular Prevention. 2015 ; Vol. 22, No. 2. pp. 129-134.
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