TY - JOUR
T1 - Relationship between short-term blood pressure variability and large-Artery stiffness in human hypertension
T2 - Findings from 2 large databases
AU - Schillaci, Giuseppe
AU - Bilo, Grzegorz
AU - Pucci, Giacomo
AU - Laurent, Stéphane
AU - MacQuin-Mavier, Isabelle
AU - Boutouyrie, Pierre
AU - Battista, Francesca
AU - Settimi, Laura
AU - Desamericq, Gaëlle
AU - Dolbeau, Guillaume
AU - Faini, Andrea
AU - Salvi, Paolo
AU - Mannarino, Elmo
AU - Parati, Gianfranco
PY - 2012/8
Y1 - 2012/8
N2 - Short-term blood pressure (BP) variability predicts cardiovascular complications in hypertension, but its association with large-Artery stiffness is poorly understood and confounded by methodologic issues related to the assessment of BP variations over 24 hours. Carotid-femoral pulse wave velocity (cfPWV) and 24-hour ambulatory BP were measured in 911 untreated, nondiabetic patients with uncomplicated hypertension (learning population) and in 2089 mostly treated hypertensive patients (83% treated, 25% diabetics; test population). Short-term systolic BP (SBP) variability was calculated as the following: (1) SD of 24-hour, daytime, or nighttime SBP; (2) weighted SD of 24-hour SBP; and (3) average real variability (ARV), that is, the average of the absolute differences between consecutive SBP measurements over 24 hours. In the learning population, all of the measures of SBP variability showed a direct correlation with cfPWV (SD of 24-hour, daytime, and nighttime SBP, r=0.17/0.19/0.13; weighted SD of 24-hour SBP, r=0.21; ARV, r=0.26; all P
AB - Short-term blood pressure (BP) variability predicts cardiovascular complications in hypertension, but its association with large-Artery stiffness is poorly understood and confounded by methodologic issues related to the assessment of BP variations over 24 hours. Carotid-femoral pulse wave velocity (cfPWV) and 24-hour ambulatory BP were measured in 911 untreated, nondiabetic patients with uncomplicated hypertension (learning population) and in 2089 mostly treated hypertensive patients (83% treated, 25% diabetics; test population). Short-term systolic BP (SBP) variability was calculated as the following: (1) SD of 24-hour, daytime, or nighttime SBP; (2) weighted SD of 24-hour SBP; and (3) average real variability (ARV), that is, the average of the absolute differences between consecutive SBP measurements over 24 hours. In the learning population, all of the measures of SBP variability showed a direct correlation with cfPWV (SD of 24-hour, daytime, and nighttime SBP, r=0.17/0.19/0.13; weighted SD of 24-hour SBP, r=0.21; ARV, r=0.26; all P
KW - arterial stiffness
KW - average real variability
KW - blood pressure
KW - blood pressure variability
KW - pulse wave velocity
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U2 - 10.1161/HYPERTENSIONAHA.112.197491
DO - 10.1161/HYPERTENSIONAHA.112.197491
M3 - Article
C2 - 22753222
AN - SCOPUS:84864288109
VL - 60
SP - 369
EP - 377
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -