Relationship between short-term blood pressure variability and large-Artery stiffness in human hypertension: Findings from 2 large databases

Giuseppe Schillaci, Grzegorz Bilo, Giacomo Pucci, Stéphane Laurent, Isabelle MacQuin-Mavier, Pierre Boutouyrie, Francesca Battista, Laura Settimi, Gaëlle Desamericq, Guillaume Dolbeau, Andrea Faini, Paolo Salvi, Elmo Mannarino, Gianfranco Parati

Research output: Contribution to journalArticlepeer-review

Abstract

Short-term blood pressure (BP) variability predicts cardiovascular complications in hypertension, but its association with large-Artery stiffness is poorly understood and confounded by methodologic issues related to the assessment of BP variations over 24 hours. Carotid-femoral pulse wave velocity (cfPWV) and 24-hour ambulatory BP were measured in 911 untreated, nondiabetic patients with uncomplicated hypertension (learning population) and in 2089 mostly treated hypertensive patients (83% treated, 25% diabetics; test population). Short-term systolic BP (SBP) variability was calculated as the following: (1) SD of 24-hour, daytime, or nighttime SBP; (2) weighted SD of 24-hour SBP; and (3) average real variability (ARV), that is, the average of the absolute differences between consecutive SBP measurements over 24 hours. In the learning population, all of the measures of SBP variability showed a direct correlation with cfPWV (SD of 24-hour, daytime, and nighttime SBP, r=0.17/0.19/0.13; weighted SD of 24-hour SBP, r=0.21; ARV, r=0.26; all P

Original languageEnglish
Pages (from-to)369-377
Number of pages9
JournalHypertension
Volume60
Issue number2
DOIs
Publication statusPublished - Aug 2012

Keywords

  • arterial stiffness
  • average real variability
  • blood pressure
  • blood pressure variability
  • pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine

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