Abstract
Background: Spectral analysis of RR interval and systolic arterial pressure variabilities may provide indirect markers of the balance between sympathetic and vagal cardiovascular control. Methods and Results: We examined the relationship between power spectral measurements of variabilities in RR interval, systolic arterial pressure, and muscle sympathetic nerve activity (MSNA) obtained by microneurography over a range of blood pressures. In eight healthy human volunteers, MSNA, RR interval, intra-arterial pressure, and respiration were measured during blood pressure reductions induced by nitroprusside and during blood pressure increases induced by phenylephrine. Both low-frequency (LF; 0.10±0.01 Hz) and high- frequency (HF; 0.23±0.01 Hz) components were detected in MSNA variability. Increasing levels of MSNA were associated with a shift of the spectral power toward its LF component. Decreasing levels of MSNA were associated with a shift of MSNA spectral power toward the HF component. Over the range of pressure changes, the LF component of MSNA variability was positively and tightly correlated with LF components of RR interval (in normalized units; P-6) and of systolic arterial pressure variability (both in millimeters of mercury squared and normalized units; P-5 and P-6, respectively). The HF component of MSNA variability was positively and tightly correlated with the HF component (in normalized units) of RR- interval variability (P-4) and of systolic arterial pressure variability (P
| Original language | English |
|---|---|
| Pages (from-to) | 1441-1448 |
| Number of pages | 8 |
| Journal | Circulation |
| Volume | 95 |
| Issue number | 6 |
| Publication status | Published - 1997 |
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Keywords
- blood pressure
- heart rate
- nervous system, autonomic
- vagus nerve
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. / Pagani, Massimo; Montano, Nicola; Porta, Alberto; Malliani, Alberto; Abboud, Francois M.; Birkett, Clay; Somers, Virend K.
In: Circulation, Vol. 95, No. 6, 1997, p. 1441-1448.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans
AU - Pagani, Massimo
AU - Montano, Nicola
AU - Porta, Alberto
AU - Malliani, Alberto
AU - Abboud, Francois M.
AU - Birkett, Clay
AU - Somers, Virend K.
PY - 1997
Y1 - 1997
N2 - Background: Spectral analysis of RR interval and systolic arterial pressure variabilities may provide indirect markers of the balance between sympathetic and vagal cardiovascular control. Methods and Results: We examined the relationship between power spectral measurements of variabilities in RR interval, systolic arterial pressure, and muscle sympathetic nerve activity (MSNA) obtained by microneurography over a range of blood pressures. In eight healthy human volunteers, MSNA, RR interval, intra-arterial pressure, and respiration were measured during blood pressure reductions induced by nitroprusside and during blood pressure increases induced by phenylephrine. Both low-frequency (LF; 0.10±0.01 Hz) and high- frequency (HF; 0.23±0.01 Hz) components were detected in MSNA variability. Increasing levels of MSNA were associated with a shift of the spectral power toward its LF component. Decreasing levels of MSNA were associated with a shift of MSNA spectral power toward the HF component. Over the range of pressure changes, the LF component of MSNA variability was positively and tightly correlated with LF components of RR interval (in normalized units; P-6) and of systolic arterial pressure variability (both in millimeters of mercury squared and normalized units; P-5 and P-6, respectively). The HF component of MSNA variability was positively and tightly correlated with the HF component (in normalized units) of RR- interval variability (P-4) and of systolic arterial pressure variability (P
AB - Background: Spectral analysis of RR interval and systolic arterial pressure variabilities may provide indirect markers of the balance between sympathetic and vagal cardiovascular control. Methods and Results: We examined the relationship between power spectral measurements of variabilities in RR interval, systolic arterial pressure, and muscle sympathetic nerve activity (MSNA) obtained by microneurography over a range of blood pressures. In eight healthy human volunteers, MSNA, RR interval, intra-arterial pressure, and respiration were measured during blood pressure reductions induced by nitroprusside and during blood pressure increases induced by phenylephrine. Both low-frequency (LF; 0.10±0.01 Hz) and high- frequency (HF; 0.23±0.01 Hz) components were detected in MSNA variability. Increasing levels of MSNA were associated with a shift of the spectral power toward its LF component. Decreasing levels of MSNA were associated with a shift of MSNA spectral power toward the HF component. Over the range of pressure changes, the LF component of MSNA variability was positively and tightly correlated with LF components of RR interval (in normalized units; P-6) and of systolic arterial pressure variability (both in millimeters of mercury squared and normalized units; P-5 and P-6, respectively). The HF component of MSNA variability was positively and tightly correlated with the HF component (in normalized units) of RR- interval variability (P-4) and of systolic arterial pressure variability (P
KW - blood pressure
KW - heart rate
KW - nervous system, autonomic
KW - vagus nerve
UR - http://www.scopus.com/inward/record.url?scp=0030900602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030900602&partnerID=8YFLogxK
M3 - Article
C2 - 9118511
AN - SCOPUS:0030900602
VL - 95
SP - 1441
EP - 1448
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 6
ER -