Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium.

Cristina Maxia, Maria Teresa Perra, Paolo Demurtas, Luigi Minerba, Daniela Murtas, Franca Piras, Renè Cabrera, Domenico Ribatti, Paola Sirigu

Research output: Contribution to journalArticlepeer-review


PURPOSE: To investigate the expression of cyclooxygenase-2 (COX-2) in a group of 93 Ecuadorian primary pterygia and to evaluate a possible association between COX-2 and survivin. METHODS: Primary pterygium samples were treated for the immunohistochemical evaluation of COX-2 and survivin. Mouse monoclonal antibody to COX-2 and rabbit polyclonal antibody to survivin were used. Statistical analysis was performed using the SPSS statistical software package, version 15.0. RESULTS: In our study, 63 (67.7%) primary pterygia samples were positive for COX-2 staining, and 70 (75.3%) specimens were positive for survivin expression. In the group of pterygia with survivin immunostaining, there were 55 (78.6%) samples with COX-2 expression. The staining of both COX-2 and survivin was localized in the lower and middle layers of the epithelium. When analyzed by Fisher's exact test, the expression of COX-2 showed a strong significant correlation with survivin (p=0.0002). CONCLUSIONS: These data, showing a significant correlation between COX-2 and survivin in primary pterygium, suggest that pterygium may originate through an anti-apoptotic mechanism.

Original languageEnglish
Pages (from-to)458-463
Number of pages6
JournalMolecular Vision
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Ophthalmology


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