Relationship between tissue glycation measured by autofluorescence and pulse wave velocity in young and elderly non-diabetic populations

G. Watfa, G. Soulis, E. Tartagni, A. Kearney-Schwartz, C. Borghi, P. Salvi, A. Benetos

Research output: Contribution to journalArticle

Abstract

Objective: Advanced glycation end-products (AGEs) and pulse wave velocity (PWV) are pivotal indices of the processes of arterial ageing and damage accumulation. The aim of the present study was to investigate the impact of AGEs, as measured by a non-invasive skin autofluorescence method, on arterial stiffness, estimated by PWV, in two different age groups of non-diabetic subjects. Methods and patients: A total of 116 non-diabetic subjects were classified into two groups, with 55 subjects in the group aged <65 years and 61 in the group aged ≥ 65 years. AGEs were measured by skin autofluorescence while carotid-femoral PWV was assessed by tonometry. Results: A significant (positive) association was observed between PWV and AGE skin autofluorescence in the younger age group (r = 0.51; P

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalDiabetes and Metabolism
Volume38
Issue number5
DOIs
Publication statusPublished - Nov 2012

Keywords

  • AGEs
  • Elderly
  • Non-diabetic
  • Pulse wave velocity
  • PVW

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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