Relationship between use of proton pump inhibitors and igf system in older subjects

Marcello Maggio, F. Lauretani, F. De Vita, V. Butto, C. Cattabiani, S. Masoni, E. Sutti, G. Bondi, E. Dall'Aglio, S. Bandinelli, A. Corsonello, A. M. Abbatecola, F. Lattanzio, L. Ferrucci, G. P. Ceda

Research output: Contribution to journalArticlepeer-review


Objectives: to investigate the effects of proton pump inhibitors (PPIs) on the insulin-like-growth factor 1(IGF-1) system in the elderly. Design: cross-sectional. Setting: InCHIANTI study. Participants: 938 older subjects (536 women, 402 men, mean age 75.7±7.4 years). Measurements: complete data on age, sex, BMI, liver function, medications, dietary intake, IGF-1, IGF-binding protein-1 and -3 (IGFBP-1, IGFBP-3). Results: Participants were categorized by PPI use, identifying 903 PPI non users and 35 users. After adjusting for age, male PPI users (107.0 ± 69.6 vs 127.1 ± 55.8, p

Original languageEnglish
Pages (from-to)420-423
Number of pages4
JournalJournal of Nutrition, Health and Aging
Issue number4
Publication statusPublished - 2014


  • IGF-1
  • Older subjects
  • Proton pump inhibitors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology
  • Medicine(all)


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