Relationship between vitamin D status and left ventricular geometry in a healthy population: Results from the Baltimore Longitudinal Study of Aging

P. Ameri, M. Canepa, Y. Milaneschi, P. Spallarossa, G. Leoncini, F. Giallauria, J. B. Strait, E. G. Lakatta, C. Brunelli, G. Murialdo, L. Ferrucci

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community-dwelling subjects without heart disease. Design: The relationship between concentrations of 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D reserve, and LV transthoracic echocardiography measures was analysed in 711 participants in the Baltimore Longitudinal Study of Aging who were without cardiac disease. Results: Mean 25(OH)D in the study population was 32.3 ± 11.4 ng mL-1; only 15.5% of subjects had moderate or severe vitamin D deficiency [25(OH)D -1]. Adjusting for age, body mass index, cardiovascular disease risk factors, physical activity, calcium and parathyroid hormone, 25(OH)D was positively correlated with LV thickness (β 0.095, SE 0.039, P -1 [odds ratio (OR) 1.24; 95% confidence interval (CI) 0.83-1.85] or ≥38 ng mL-1 (OR 1.73; 95% CI 1.13-2.65), compared with those with 30-37 ng mL-1 25(OH)D. Consistently, LV relative wall thickness was significantly lower (P for trend=0.05), and LV diastolic internal diameter index (P for trend-1 25(OH)D compared to the rest of the study population. There was a significant interaction between 25(OH)D and hypertension on the risk of LV hypertrophy (P 

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalJournal of Internal Medicine
Volume273
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Heart
  • Left ventricular mass
  • Left ventricular remodelling
  • Population
  • Vitamin D

ASJC Scopus subject areas

  • Internal Medicine

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