Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hypertension

Gianfranco Parati, Guido Pomidossi, Fabio Albini, Daniele Malaspina, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Casual blood pressure (BP) can predict the development of cardiovascular morbidity and mortality, but the correlations between its values and the subsequent occurrence of such complications are low. This may depend on different individual resistance to the damage produced by hypertension. However, it may also depend on the recognized inability of casual BP to reflect accurately the 24-h mean and profile BP. In order to test the latter hypothesis, 24-h BP was recorded intra-arterially (Oxford method) in 108 hospitalized subjects with essential hypertension ranging from mild to severe. The 24-h means and standard deviations (i.e. variabilities) for systolic, mean and diastolic BP obtained by computer analysis of the BP tracing were related to the rate and severity of target-organ damage (TOD) assessed by clinical examination and quantified according to a predetermined score. The results confirmed that 24-h BP may be variably different from cuff BP among subjects. For nearly any value of cuff BP, subjects in whom the 24-h mean BP was low had a lower prevalence and severity of TOD than those in whom the 24-h mean BP was high (P

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalJournal of Hypertension
Issue number1
Publication statusPublished - 1987


  • Ambulatory blood pressure monitoring
  • Blood pressure
  • Blood pressure variability
  • Cardiovascular morbidity
  • Cardiovascular risk factors
  • Hypertension
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology


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