Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: The European Prospective Investigation into Cancer and Nutrition

S. Rinaldi, P. H M Peeters, I. D. Bezemer, L. Dossus, C. Biessy, C. Sacerdote, F. Berrino, S. Panico, D. Palli, R. Tumino, K. T. Khaw, S. Bingham, N. E. Allen, T. Key, M. K. Jensen, K. Overvad, A. Olsen, A. Tjonneland, P. Amiano, E. ArdanazA. Agudo, C. Martinez-García, J. Ramón Quirós, M. J. Tormo, G. Nagel, J. Linseisen, H. Boeing, M. Schulz, D. E. Grobbee, H. B. Bueno-De-Mesquita, M. Koliva, G. Kyriazi, A. Thrichopoulou, M. C. Boutron-Ruault, F. Clavel-Chapelon, P. Ferrari, N. Slimani, R. Saracci, E. Riboli, R. Kaaks

Research output: Contribution to journalArticle

Abstract

Objective: Women with a moderate intake of alcohol have higher concentrations of sex steroids in serum, and higher risk of developing breast cancer, compared to non-drinkers. In the present study, we investigate the relationships between alcohol consumption and serum levels of sex steroids and sex-hormone binding globulin (SHBG) in 790 pre- and 1,291 post-menopausal women, who were part of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Serum levels of testosterone (T), androstenedione (Δ4), dehydroepiandrosterone sulphate (DHEAS), estrone (E 1), estradiol (E2) and SHBG were measured by direct immunoassays. Free T (fT) and free E2 (fE2) were calculated according to mass action laws. Current alcohol intake exposure to alcohol was assessed from dietary questionnaires. Results: Pre-menopausal women who consumed more than 25 g/day of alcohol had about 30% higher DHEAS, T and fT, 20% higher Δ4 and about 40% higher E1, concentrations compared to women who were non-consumers. E2, fE 2 and SHBG concentrations showed no association with current alcohol intake. In post-menopausal women, DHEAS, fT, T, Δ4, and E 1 concentrations were between 10% and 20% higher in women who consumed more than 25 g/day of alcohol compared to non-consumers. E2 or fE2 were not associated with alcohol intake at all. SHBG levels were about 15% lower in alcohol consumers compared to non-consumers. Conclusion: This study supports the hypothesis of an influence of alcohol intake on sex hormone concentrations in blood.

Original languageEnglish
Pages (from-to)1033-1043
Number of pages11
JournalCancer Causes and Control
Volume17
Issue number8
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Alcohol intake
  • Post-menopausal women
  • Pre-menopausal
  • Sex steroids

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

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    Rinaldi, S., Peeters, P. H. M., Bezemer, I. D., Dossus, L., Biessy, C., Sacerdote, C., Berrino, F., Panico, S., Palli, D., Tumino, R., Khaw, K. T., Bingham, S., Allen, N. E., Key, T., Jensen, M. K., Overvad, K., Olsen, A., Tjonneland, A., Amiano, P., ... Kaaks, R. (2006). Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: The European Prospective Investigation into Cancer and Nutrition. Cancer Causes and Control, 17(8), 1033-1043. https://doi.org/10.1007/s10552-006-0041-7