Relationship of serum lactate dehydrogenase level with first remission length in adult acute lymphocytic leukaemia

G. Fasola, R. Fanin, M. Baccarani, E. Zuffa, C. Haanen, B. Comotti, G. Scapoli, A. Alghisi, R. Battista, M. Aieta

Research output: Contribution to journalArticle

Abstract

Several features have a prognostic value in adults with acute lymphocytic leukaemia (ALL). However, in about two-thirds of all cases prognosis remains quite variable, with a substantial number of early relapses. This study shows in 118 adult patients who attained complete remission (CR) between 1978 and 1984 that pretreatment serum total lactate dehydrogenase (LDH) activity was inversely correlated with first CR length. The prognostic value of LDH was higher than that of any other features both in univariable and in multivariable analysis. The value was significant in the whole series as well as in patients who lacked other high risk features. Among non-high risk and low-WBC count cases, patients with LDH ≤ 500 U/l had a median first CR duration of 27 months, and a projected 5-year relapse free survival of 36%, versus 9 months and 12% of patients with LDH > 500 U/l. These results fit well with the results of a study of ALL in children, and suggest that pretreatment serum total LDH activity is an important risk determinant in adult ALL.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalBritish Journal of Haematology
Volume66
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Hematology

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    Fasola, G., Fanin, R., Baccarani, M., Zuffa, E., Haanen, C., Comotti, B., Scapoli, G., Alghisi, A., Battista, R., & Aieta, M. (1987). Relationship of serum lactate dehydrogenase level with first remission length in adult acute lymphocytic leukaemia. British Journal of Haematology, 66(1), 49-53.