Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects

Bruno Ambrosi; B. Masserini; L. Iorio; A. Delnevo; A. E. Malavazos; L. Morricone; L. F. Sburlati; E. Orsi

doi:10.3275/6952

Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects

Bruno Ambrosi, B. Masserini, L. Iorio, A. Delnevo, A. E. Malavazos, L. Morricone, L. F. Sburlati, E. Orsi

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T₄ (FT₄) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT₄ levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p

Original language	English
Pages (from-to)	640-643
Number of pages	4
Journal	Journal of Endocrinological Investigation
Volume	33
Issue number	9
DOIs	https://doi.org/10.3275/6952
Publication status	Published - Oct 2010

Keywords

BMI
Insulin resistance
Obesity
Overweight
Thyroid hormones
TSH

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.3275/6952

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title = "Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects",

abstract = "Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p",

keywords = "BMI, Insulin resistance, Obesity, Overweight, Thyroid hormones, TSH",

author = "Bruno Ambrosi and B. Masserini and L. Iorio and A. Delnevo and Malavazos, {A. E.} and L. Morricone and Sburlati, {L. F.} and E. Orsi",

year = "2010",

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doi = "10.3275/6952",

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AU - Ambrosi, Bruno

AU - Masserini, B.

AU - Iorio, L.

AU - Delnevo, A.

AU - Malavazos, A. E.

AU - Morricone, L.

AU - Sburlati, L. F.

AU - Orsi, E.

PY - 2010/10

Y1 - 2010/10

N2 - Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p

AB - Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p

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KW - Insulin resistance

KW - Obesity

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KW - Thyroid hormones

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Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects

Abstract

Keywords

ASJC Scopus subject areas

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