Abstract
Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p
| Original language | English |
|---|---|
| Pages (from-to) | 640-643 |
| Number of pages | 4 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 33 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Oct 2010 |
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Keywords
- BMI
- Insulin resistance
- Obesity
- Overweight
- Thyroid hormones
- TSH
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects. / Ambrosi, Bruno; Masserini, B.; Iorio, L.; Delnevo, A.; Malavazos, A. E.; Morricone, L.; Sburlati, L. F.; Orsi, E.
In: Journal of Endocrinological Investigation, Vol. 33, No. 9, 10.2010, p. 640-643.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects
AU - Ambrosi, Bruno
AU - Masserini, B.
AU - Iorio, L.
AU - Delnevo, A.
AU - Malavazos, A. E.
AU - Morricone, L.
AU - Sburlati, L. F.
AU - Orsi, E.
PY - 2010/10
Y1 - 2010/10
N2 - Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p
AB - Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p
KW - BMI
KW - Insulin resistance
KW - Obesity
KW - Overweight
KW - Thyroid hormones
KW - TSH
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UR - http://www.scopus.com/inward/citedby.url?scp=78751698068&partnerID=8YFLogxK
U2 - 10.3275/6952
DO - 10.3275/6952
M3 - Article
C2 - 20339314
AN - SCOPUS:78751698068
VL - 33
SP - 640
EP - 643
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 9
ER -