Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects

Bruno Ambrosi, B. Masserini, L. Iorio, A. Delnevo, A. E. Malavazos, L. Morricone, L. F. Sburlati, E. Orsi

Research output: Contribution to journalArticle

Abstract

Background and aims: It is recognized that overt thyroid dysfunction is associated with weight changes, but the influence of a minor alteration of thyroid function remains unclear. This study aimed to further investigate the relationship between obesity and thyroid function and to examine the possible role of insulin resistance on the hypothalamic-pituitary-thyroid axis. Methods and results: Serum TSH and free T4 (FT4) levels, anthropometric and metabolic parameters were evaluated in 581 obese patients. In all patients TSH values progressively increased according to the severity of obesity and were positively correlated with body mass index (p=0.001, r=0.13) and waist circumference (p=0.02, r=0.11). Patients with insulin resistance showed higher TSH (1.8±1.0 vs 1.6±0.9 μUI/l; p=0.03) and lower FT4 levels (13.8±2.3 vs 15.0±2.2 pmol/l; p4 was negatively associated with fasting insulin (p

Original languageEnglish
Pages (from-to)640-643
Number of pages4
JournalJournal of Endocrinological Investigation
Volume33
Issue number9
DOIs
Publication statusPublished - Oct 2010

Keywords

  • BMI
  • Insulin resistance
  • Obesity
  • Overweight
  • Thyroid hormones
  • TSH

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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