Relationships among tumor load, route of tumor inoculation, and response to immunochemotherapy in a murine lymphoma model

P. Marconi, A. Cassone, M. Baccarini, L. Tissi, E. Garaci, E. Bonmassar, L. Frati, F. Bistoni

Research output: Contribution to journalArticle

Abstract

The combined effects of nonspecific immunostimulation with Candida albicans (CA) and chemotherapy were studied in (BALB/cCr x DBA/2Cr)F1 and (C57BL/6Cr x DBA/2Cr)F1 mice bearing virus-induced LSTRA lymphomas. Paradoxically, animals treated with a relatively high number of tumor cells responded better to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea) (BCNU) than those challenged with a low number of tumor cells. However, the majority of mice subjected to low initial tumor load were cured when they were treated with chemotherapy plus booster injection of CA at a relatively 'late' stage of the disease, i.e., when high tumor load was present in tumor-bearing hosts. It has been shown that this phenomenon, provisionally called high tumor load protection, occurs when the animals are challenged ip but not when they are challenged iv with the tumor and is abolished by total-body γ-irradiation. Moreover, marked host protection can be attained when immunostimulated mice, inoculated iv with lymphoma cells, are subjected to simultaneous challenge with high inocula of the same tumor ip, followed by BCNU administration. These data stress the importance of the peritoneal cavity of successful CA plus drug treatment and suggest that optimal tumor 'antigen load' should be present at the time of CA and/or BCNU administration.

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalJournal of the National Cancer Institute
Volume71
Issue number2
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Marconi, P., Cassone, A., Baccarini, M., Tissi, L., Garaci, E., Bonmassar, E., Frati, L., & Bistoni, F. (1983). Relationships among tumor load, route of tumor inoculation, and response to immunochemotherapy in a murine lymphoma model. Journal of the National Cancer Institute, 71(2), 299-307.