Relationships between B cell cytokine production in secondary lymphoid follicles and apoptosis of germinal center B lymphocytes

V. Pistoia, A. Corcione

Research output: Contribution to journalArticle

Abstract

In vivo or in vitro activated human B lymphocytes can produce a wide spectrum of cytokines which are involved in the regulation of hematopoiesis and of the inflammatory and immune responses. Three major B cell subsets have been identified in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MZ) and the marginal zone B lymphocytes. GC and MZ B cells can be isolated as CD39- surface (s)IgD- or CD39-, sIgD- cells, respectively. Therefore, it is now possible to investigate the cytokine producing potential of purified GC and MZ B lymphocytes. In this article, the optimal conditions for the assessment of cytokine production by human B cells are first discussed; thereafter, the spectrum of B lymphocyte-derived cytokines is described together with their possible physiological meaning. Next, data concerning the cytokines released in vitro by either GC or MZ B cells are presented. Some cytokines, such as granulocyte colony stimulating factor (G- CSF) or granulocyte-macrophage CSF (GM-CSF), are produced only by GC or MZ B lymphocytes, respectively, whereas other cytokines, such as tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) or IL-10 are synthesized by both B cell subsets. Finally, the relationships between B cell-derived cytokines and apoptosis of GC B lymphocytes are discussed, and a hypothetical model of the cytokine networks in secondary lymphoid follicles is presented. It is expected that these notions will help to clarify the pathophysiology of lymphoproliferative and autoimmune diseases.

Original languageEnglish
Pages (from-to)487-500
Number of pages14
JournalStem Cells
Volume13
Issue number5
Publication statusPublished - 1995

Fingerprint

Germinal Center
B-Lymphocytes
Apoptosis
Cytokines
B-Lymphocyte Subsets
Immunoglobulin D
Hematopoiesis
Granulocyte Colony-Stimulating Factor
Granulocytes
Interleukin-10
Autoimmune Diseases
Interleukin-6
Tumor Necrosis Factor-alpha
Macrophages

Keywords

  • B lymphocytes
  • Cytokines
  • Germinal center
  • Lymphoid follicles
  • Mantle zone

ASJC Scopus subject areas

  • Cell Biology

Cite this

Relationships between B cell cytokine production in secondary lymphoid follicles and apoptosis of germinal center B lymphocytes. / Pistoia, V.; Corcione, A.

In: Stem Cells, Vol. 13, No. 5, 1995, p. 487-500.

Research output: Contribution to journalArticle

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