Abstract
Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 199-206 |
| Number of pages | 8 |
| Journal | Acta Diabetologica Latina |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1981 |
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Keywords
- Beta-thromboglobulin
- Diabetic complications
- Diabetic control
- Factor-VIII procoagulant activity
- Factor-VIII related antigen
- Hemoglobin A
- High density lipoprotein-cholesterol
- Triglycerides
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Relationships between metabolic and hemostatic variables in uncomplicated diabetes. / Vergani, Carlo; Bettale, Giusy; Mari, Daniela; Mannucci, Pier Mannuccio.
In: Acta Diabetologica Latina, Vol. 18, No. 3, 07.1981, p. 199-206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationships between metabolic and hemostatic variables in uncomplicated diabetes
AU - Vergani, Carlo
AU - Bettale, Giusy
AU - Mari, Daniela
AU - Mannucci, Pier Mannuccio
PY - 1981/7
Y1 - 1981/7
N2 - Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.
AB - Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.
KW - Beta-thromboglobulin
KW - Diabetic complications
KW - Diabetic control
KW - Factor-VIII procoagulant activity
KW - Factor-VIII related antigen
KW - Hemoglobin A
KW - High density lipoprotein-cholesterol
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=0019843342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019843342&partnerID=8YFLogxK
U2 - 10.1007/BF02047890
DO - 10.1007/BF02047890
M3 - Article
C2 - 6171128
AN - SCOPUS:0019843342
VL - 18
SP - 199
EP - 206
JO - Acta Diabetologica
JF - Acta Diabetologica
SN - 0940-5429
IS - 3
ER -