Relationships between metabolic and hemostatic variables in uncomplicated diabetes

Carlo Vergani; Giusy Bettale; Daniela Mari; Pier Mannuccio Mannucci

doi:10.1007/BF02047890

Relationships between metabolic and hemostatic variables in uncomplicated diabetes

Carlo Vergani, Giusy Bettale, Daniela Mari, Pier Mannuccio Mannucci

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

Several metabolic (HbA₁, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA₁ and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.

Original language	English
Pages (from-to)	199-206
Number of pages	8
Journal	Acta Diabetologica Latina
Volume	18
Issue number	3
DOIs	https://doi.org/10.1007/BF02047890
Publication status	Published - Jul 1981

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Keywords

Beta-thromboglobulin
Diabetic complications
Diabetic control
Factor-VIII procoagulant activity
Factor-VIII related antigen
Hemoglobin A
High density lipoprotein-cholesterol
Triglycerides

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

Cite this

Vergani, C., Bettale, G., Mari, D., & Mannucci, P. M. (1981). Relationships between metabolic and hemostatic variables in uncomplicated diabetes. Acta Diabetologica Latina, 18(3), 199-206. https://doi.org/10.1007/BF02047890

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N2 - Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.

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10.1007/BF02047890