Relationships between metabolic and hemostatic variables in uncomplicated diabetes

Carlo Vergani, Giusy Bettale, Daniela Mari, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle

Abstract

Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalActa Diabetologica Latina
Volume18
Issue number3
DOIs
Publication statusPublished - Jul 1981

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Keywords

  • Beta-thromboglobulin
  • Diabetic complications
  • Diabetic control
  • Factor-VIII procoagulant activity
  • Factor-VIII related antigen
  • Hemoglobin A
  • High density lipoprotein-cholesterol
  • Triglycerides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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