Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: An observational, exploratory study in 404 subjects

Annamaria Colao, Carolina Di Somma, Teresa Cascella, Rosario Pivonello, Giovanni Vitale, Ludovica F S Grasso, Gaetano Lombardi, Silvia Savastano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality. Objective: To investigate the relationships between IGF1 levels, blood pressure (BP), and glucose tolerance (GT). Subjects: Four-hundred and four subjects (200 men aged 18-80 years). Exclusion criteria: personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (> 2 weeks), estrogens, or testosterone (> 12 weeks); smoking of > 15 cigarettes/day and alcohol abuse (> 3 glasses of wine/day). Results: Two hundred and ninety-six had normal BP (73.3%), 86 had mild (21.3%), and 22 had severe (5.4%) hypertension; 322 had normal GT (NGT (79.7%)), 53 had impaired glucose tolerance (IGT (13.1%)), 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF1 levels (0.11±0.94 SDS) than those with mild (-0.62±1.16 SDS, P

Original languageEnglish
Pages (from-to)389-397
Number of pages9
JournalEuropean Journal of Endocrinology
Volume159
Issue number4
DOIs
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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