Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: An observational, exploratory study in 404 subjects

Annamaria Colao, Carolina Di Somma, Teresa Cascella, Rosario Pivonello, Giovanni Vitale, Ludovica F S Grasso, Gaetano Lombardi, Silvia Savastano

Research output: Contribution to journalArticle

Abstract

Background: In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality. Objective: To investigate the relationships between IGF1 levels, blood pressure (BP), and glucose tolerance (GT). Subjects: Four-hundred and four subjects (200 men aged 18-80 years). Exclusion criteria: personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (> 2 weeks), estrogens, or testosterone (> 12 weeks); smoking of > 15 cigarettes/day and alcohol abuse (> 3 glasses of wine/day). Results: Two hundred and ninety-six had normal BP (73.3%), 86 had mild (21.3%), and 22 had severe (5.4%) hypertension; 322 had normal GT (NGT (79.7%)), 53 had impaired glucose tolerance (IGT (13.1%)), 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF1 levels (0.11±0.94 SDS) than those with mild (-0.62±1.16 SDS, P

Original languageEnglish
Pages (from-to)389-397
Number of pages9
JournalEuropean Journal of Endocrinology
Volume159
Issue number4
DOIs
Publication statusPublished - Oct 2008

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Observational Studies
Blood Glucose
Blood Pressure
Cardiovascular Diseases
Serum
Pituitary Diseases
Glucose Intolerance
Wine
Tobacco Products
Alcoholism
Glass
Testosterone
Diabetes Mellitus
Adrenal Cortex Hormones
Estrogens
Smoking
Hypertension
Lipids
Glucose
Mortality

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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Relationships between serum IGF1 levels, blood pressure, and glucose tolerance : An observational, exploratory study in 404 subjects. / Colao, Annamaria; Di Somma, Carolina; Cascella, Teresa; Pivonello, Rosario; Vitale, Giovanni; Grasso, Ludovica F S; Lombardi, Gaetano; Savastano, Silvia.

In: European Journal of Endocrinology, Vol. 159, No. 4, 10.2008, p. 389-397.

Research output: Contribution to journalArticle

Colao, Annamaria ; Di Somma, Carolina ; Cascella, Teresa ; Pivonello, Rosario ; Vitale, Giovanni ; Grasso, Ludovica F S ; Lombardi, Gaetano ; Savastano, Silvia. / Relationships between serum IGF1 levels, blood pressure, and glucose tolerance : An observational, exploratory study in 404 subjects. In: European Journal of Endocrinology. 2008 ; Vol. 159, No. 4. pp. 389-397.
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