Relationships between 99mTc-HMPAO CERASPECT and quantitative EEG observations in Alzheimer's disease

F. Nobili, G. Taddei, P. Vitali, L. Bazzano, E. Catsafados, G. Mariani, G. Rodriguez

Research output: Contribution to journalArticle

Abstract

Nineteen patients affected with probable Alzheimer's disease (AD) underwent quantitative electroencephalography (qEEG) and semiquantitative regional cerebral blood flow (rCBF) measurement by 99mTc-HMPAO (hexamethyl-propylene amine-oxine) SPECT by a high resolution device (CERASPECT). Perfusional and EEG data were correlated with one another and with the severity of disease, as expressed by the mini mental state examination (MMSE), in a posterior temporoparietal region of interest (ROI) in either of the hemispheres. Moreover, qEEG was also correlated with rCBF in a thalamic and a hippocampal ROI. Both qEEG and rCBF data were significantly correlated to MMSE, especially in the left hemisphere. The qEEG and rCBF results were correlated in the temporoparietal ROI, mainly in the left one, whereas no correlation was found between thalamic ROI and qEEG and only the right hippocampal ROI was slightly related to qEEG. Both techniques are confirmed to be reliable tools in assessing brain failure in AD, and qEEG may be conveniently employed where SPECT is unavailable. Staging a given patient in respect with the course of the disease by means of a multiple neurophysiological approach may overcome the limitations of individual techniques, which appears to be particularly relevant for the evaluation of the impact of eventual future effective treatment.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalArchives of Gerontology and Geriatrics
Volume27
Issue numberSUPPL. 6
Publication statusPublished - 1998

Keywords

  • Alzheimer's disease
  • Quantitative electroencephalography
  • Regional cerebral blood flow
  • SPECT method

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Fingerprint Dive into the research topics of 'Relationships between <sup>99m</sup>Tc-HMPAO CERASPECT and quantitative EEG observations in Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this

    Nobili, F., Taddei, G., Vitali, P., Bazzano, L., Catsafados, E., Mariani, G., & Rodriguez, G. (1998). Relationships between 99mTc-HMPAO CERASPECT and quantitative EEG observations in Alzheimer's disease. Archives of Gerontology and Geriatrics, 27(SUPPL. 6), 363-368.