Relative and disease-free survival for breast cancer in relation to subtype: A population-based study

Pamela Minicozzi, Francesca Bella, Angela Toss, Adriano Giacomin, Mario Fusco, Maurizio Zarcone, Rosario Tumino, Fabio Falcini, Rosaria Cesaraccio, Giuseppa Candela, Francesco La Rosa, Massimo Federico, Milena Sant

Research output: Contribution to journalArticlepeer-review


Purpose: No population-based study has investigated breast cancer (BC) subtypes defined by including Ki67. The aim of this study was to evaluate the relative proportions of immunohistochemical subtypes and differences in relative and disease-free survival between subtypes, in relation to patient and other cancer characteristics in Italian BC patient. Methods: Information on estrogen, progesterone, human epidermal growth factor (HER2), Ki67, and relapses was obtained for 3,381 cases, sampled randomly and anonymously from cases diagnosed in 2003-2005 in nine Italian cancer registries. Relative excess risks (RERs) of death and risks of relapse 5 years after diagnosis were estimated. Results: Luminal A cancers were 42 % of the total, luminal B 27 %, luminal-HER2 14 %, triple-negative 11 %, and HER2-enriched 7 %. For non-metastatic (3,302) cases, 4 and 7 % developed locoregional and distant metastases, respectively. RERs of death and risks of relapse were significantly greater for all cancer subtypes than luminal A, particularly for triple-negative and HER2-enriched cancers, which were more frequent in women

Original languageEnglish
Pages (from-to)1569-1577
Number of pages9
JournalJournal of Cancer Research and Clinical Oncology
Issue number9
Publication statusPublished - Sep 2013


  • Breast cancer
  • HER2
  • Hormone receptor
  • Ki67
  • Population-based study
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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