Relative decrease in the role played by hepatitis B virus infection in the aetiology of hepatocellular carcinoma during a 20-year period: A multicentre Italian study

Edoardo G. Giannini, Vincenzo Savarino, Domenico Risso, Maria A. Di Nolfo, Paolo Del Poggio, Luisa Benvegnù, Fabio Farinati, Marco Zoli, Franco Borzio, Eugenio Caturelli, Maria Chiaramonte, Franco Trevisani

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3 Citations (Scopus)

Abstract

Background: Chronic hepatitis B virus (HBV) infection is one of the most frequent aetiological factors associated with the development of hepatocellular carcinoma (HCC).Aim: This study evaluated the temporal trend in the aetiological role played by HBV infection alone in patients diagnosed with HCC during the last 20 years in Italy.Methods: Among the 2042 HCC patients included in the Italian Liver Cancer (ITA.LI.CA.) database, 346 had chronic HBV infection alone. We assessed the proportion of HCC patients with HBV infection in four quinquennia (1987-1991, 1992-1996, 1997-2001, 2002-2006) and evaluated their main clinical, virological and oncological characteristics across these periods.Results: Although the absolute number increased, the proportion of HBV-related HCC relatively decreased over time from 26.7% (47/176 patients) in 1987-1991 to 14.7% (127/862 patients) in 2002-2006 (P=0.0005). Patients' demographical, clinical and virological characteristics were similar across the four quinquennia. A greater proportion of patients was diagnosed with non-advanced HCC in more recent years (from 26% in 1987-1991 to 48% in 2002-2006, P=0.025), likely owing to a growing use of semiannual surveillance (from 63% in 1987-1991 to 80% in 2002-2006).Conclusions: We observed a significant, relative decrease in the role played by chronic HBV infection alone in the determinism of HCC during the last 20 years. In recent years, more patients are diagnosed with non-advanced HCC probably owing to improvements in HCC detection.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalLiver International
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 2011

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Virus Diseases
Hepatitis B virus
Multicenter Studies
Hepatocellular Carcinoma
Chronic Hepatitis B
Liver Neoplasms
Italy
Databases

Keywords

  • Epidemiology
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Survival
  • Treatment

ASJC Scopus subject areas

  • Hepatology

Cite this

Relative decrease in the role played by hepatitis B virus infection in the aetiology of hepatocellular carcinoma during a 20-year period : A multicentre Italian study. / Giannini, Edoardo G.; Savarino, Vincenzo; Risso, Domenico; Di Nolfo, Maria A.; Del Poggio, Paolo; Benvegnù, Luisa; Farinati, Fabio; Zoli, Marco; Borzio, Franco; Caturelli, Eugenio; Chiaramonte, Maria; Trevisani, Franco.

In: Liver International, Vol. 31, No. 2, 02.2011, p. 192-196.

Research output: Contribution to journalArticle

Giannini, EG, Savarino, V, Risso, D, Di Nolfo, MA, Del Poggio, P, Benvegnù, L, Farinati, F, Zoli, M, Borzio, F, Caturelli, E, Chiaramonte, M & Trevisani, F 2011, 'Relative decrease in the role played by hepatitis B virus infection in the aetiology of hepatocellular carcinoma during a 20-year period: A multicentre Italian study', Liver International, vol. 31, no. 2, pp. 192-196. https://doi.org/10.1111/j.1478-3231.2010.02409.x
Giannini, Edoardo G. ; Savarino, Vincenzo ; Risso, Domenico ; Di Nolfo, Maria A. ; Del Poggio, Paolo ; Benvegnù, Luisa ; Farinati, Fabio ; Zoli, Marco ; Borzio, Franco ; Caturelli, Eugenio ; Chiaramonte, Maria ; Trevisani, Franco. / Relative decrease in the role played by hepatitis B virus infection in the aetiology of hepatocellular carcinoma during a 20-year period : A multicentre Italian study. In: Liver International. 2011 ; Vol. 31, No. 2. pp. 192-196.
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abstract = "Background: Chronic hepatitis B virus (HBV) infection is one of the most frequent aetiological factors associated with the development of hepatocellular carcinoma (HCC).Aim: This study evaluated the temporal trend in the aetiological role played by HBV infection alone in patients diagnosed with HCC during the last 20 years in Italy.Methods: Among the 2042 HCC patients included in the Italian Liver Cancer (ITA.LI.CA.) database, 346 had chronic HBV infection alone. We assessed the proportion of HCC patients with HBV infection in four quinquennia (1987-1991, 1992-1996, 1997-2001, 2002-2006) and evaluated their main clinical, virological and oncological characteristics across these periods.Results: Although the absolute number increased, the proportion of HBV-related HCC relatively decreased over time from 26.7{\%} (47/176 patients) in 1987-1991 to 14.7{\%} (127/862 patients) in 2002-2006 (P=0.0005). Patients' demographical, clinical and virological characteristics were similar across the four quinquennia. A greater proportion of patients was diagnosed with non-advanced HCC in more recent years (from 26{\%} in 1987-1991 to 48{\%} in 2002-2006, P=0.025), likely owing to a growing use of semiannual surveillance (from 63{\%} in 1987-1991 to 80{\%} in 2002-2006).Conclusions: We observed a significant, relative decrease in the role played by chronic HBV infection alone in the determinism of HCC during the last 20 years. In recent years, more patients are diagnosed with non-advanced HCC probably owing to improvements in HCC detection.",
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T1 - Relative decrease in the role played by hepatitis B virus infection in the aetiology of hepatocellular carcinoma during a 20-year period

T2 - A multicentre Italian study

AU - Giannini, Edoardo G.

AU - Savarino, Vincenzo

AU - Risso, Domenico

AU - Di Nolfo, Maria A.

AU - Del Poggio, Paolo

AU - Benvegnù, Luisa

AU - Farinati, Fabio

AU - Zoli, Marco

AU - Borzio, Franco

AU - Caturelli, Eugenio

AU - Chiaramonte, Maria

AU - Trevisani, Franco

PY - 2011/2

Y1 - 2011/2

N2 - Background: Chronic hepatitis B virus (HBV) infection is one of the most frequent aetiological factors associated with the development of hepatocellular carcinoma (HCC).Aim: This study evaluated the temporal trend in the aetiological role played by HBV infection alone in patients diagnosed with HCC during the last 20 years in Italy.Methods: Among the 2042 HCC patients included in the Italian Liver Cancer (ITA.LI.CA.) database, 346 had chronic HBV infection alone. We assessed the proportion of HCC patients with HBV infection in four quinquennia (1987-1991, 1992-1996, 1997-2001, 2002-2006) and evaluated their main clinical, virological and oncological characteristics across these periods.Results: Although the absolute number increased, the proportion of HBV-related HCC relatively decreased over time from 26.7% (47/176 patients) in 1987-1991 to 14.7% (127/862 patients) in 2002-2006 (P=0.0005). Patients' demographical, clinical and virological characteristics were similar across the four quinquennia. A greater proportion of patients was diagnosed with non-advanced HCC in more recent years (from 26% in 1987-1991 to 48% in 2002-2006, P=0.025), likely owing to a growing use of semiannual surveillance (from 63% in 1987-1991 to 80% in 2002-2006).Conclusions: We observed a significant, relative decrease in the role played by chronic HBV infection alone in the determinism of HCC during the last 20 years. In recent years, more patients are diagnosed with non-advanced HCC probably owing to improvements in HCC detection.

AB - Background: Chronic hepatitis B virus (HBV) infection is one of the most frequent aetiological factors associated with the development of hepatocellular carcinoma (HCC).Aim: This study evaluated the temporal trend in the aetiological role played by HBV infection alone in patients diagnosed with HCC during the last 20 years in Italy.Methods: Among the 2042 HCC patients included in the Italian Liver Cancer (ITA.LI.CA.) database, 346 had chronic HBV infection alone. We assessed the proportion of HCC patients with HBV infection in four quinquennia (1987-1991, 1992-1996, 1997-2001, 2002-2006) and evaluated their main clinical, virological and oncological characteristics across these periods.Results: Although the absolute number increased, the proportion of HBV-related HCC relatively decreased over time from 26.7% (47/176 patients) in 1987-1991 to 14.7% (127/862 patients) in 2002-2006 (P=0.0005). Patients' demographical, clinical and virological characteristics were similar across the four quinquennia. A greater proportion of patients was diagnosed with non-advanced HCC in more recent years (from 26% in 1987-1991 to 48% in 2002-2006, P=0.025), likely owing to a growing use of semiannual surveillance (from 63% in 1987-1991 to 80% in 2002-2006).Conclusions: We observed a significant, relative decrease in the role played by chronic HBV infection alone in the determinism of HCC during the last 20 years. In recent years, more patients are diagnosed with non-advanced HCC probably owing to improvements in HCC detection.

KW - Epidemiology

KW - Hepatitis B virus

KW - Hepatocellular carcinoma

KW - Survival

KW - Treatment

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