Relative iron deficiency in hereditary spherocytosis

A. Zanella, G. Barosi, A. Berzuini, M. B. Colombo, S. Quaglini, D. Volpes, G. Sirchia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seventy-three patients with hereditary spherocytosis (HS) (58 nonsplenectomized, 15 splenectomized) were studied to evaluate iron status and the adequacy of iron availability for erythropoiesis. Splenectomized patients, who had hemoglobin levels in the normal or upper normal range, had higher levels of serum iron, transferrin saturation, and serum ferritin than normal matched controls and normal zinc protoporphyrin (ZnPP) levels. On the contrary, nonsplenectomized patients presenting with mild to severe anemia had higher red cell ZnPP concentrations than both splenectomized subjects and matched normal controls. ZnPP in nonsplenectomized patients correlated inversely with Hb concentration, mean corpuscular volume (MCV), mean red cell hemoglobin concentration (MCHC), transferrin saturation, and serum iron, and directly with reticulocyte count. At multiple regression analysis only Hb concentration was a significant explanatory variable for high ZnPP. The authors conclude that a number of nonsplenectomized HS patients have relative iron deficiency primarily because of expansion of erythropoiesis caused by anemia.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalAmerican Journal of Hematology
Volume31
Issue number2
Publication statusPublished - 1989

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Hereditary Spherocytosis
Iron
Erythrocyte Indices
Erythropoiesis
Transferrin
Anemia
Serum
Reticulocyte Count
Ferritins
Reference Values
Hemoglobins
Regression Analysis
zinc protoporphyrin

ASJC Scopus subject areas

  • Hematology

Cite this

Zanella, A., Barosi, G., Berzuini, A., Colombo, M. B., Quaglini, S., Volpes, D., & Sirchia, G. (1989). Relative iron deficiency in hereditary spherocytosis. American Journal of Hematology, 31(2), 81-86.

Relative iron deficiency in hereditary spherocytosis. / Zanella, A.; Barosi, G.; Berzuini, A.; Colombo, M. B.; Quaglini, S.; Volpes, D.; Sirchia, G.

In: American Journal of Hematology, Vol. 31, No. 2, 1989, p. 81-86.

Research output: Contribution to journalArticle

Zanella, A, Barosi, G, Berzuini, A, Colombo, MB, Quaglini, S, Volpes, D & Sirchia, G 1989, 'Relative iron deficiency in hereditary spherocytosis', American Journal of Hematology, vol. 31, no. 2, pp. 81-86.
Zanella A, Barosi G, Berzuini A, Colombo MB, Quaglini S, Volpes D et al. Relative iron deficiency in hereditary spherocytosis. American Journal of Hematology. 1989;31(2):81-86.
Zanella, A. ; Barosi, G. ; Berzuini, A. ; Colombo, M. B. ; Quaglini, S. ; Volpes, D. ; Sirchia, G. / Relative iron deficiency in hereditary spherocytosis. In: American Journal of Hematology. 1989 ; Vol. 31, No. 2. pp. 81-86.
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