Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART

Andrea Antinori, Alessandro Cozzi-Lepri, Adriana Ammassari, Maria Paola Trotta, David Nauwelaers, Richard Hoetelmans, Rita Murri, Sara Melzi, Pasquale Narciso, Paola Nasta, Mauro Zaccarelli, Paola Santopadre, Jacopo Vecchiet, Crescenzo Maria Izzo, Antonella D'Arminio Monforte

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the predictive value of self-reported adherence and plasma drug concentrations on virological rebound to HAART. Among 238 participants in the AdICoNA study who had viral load ≤500 copies/ml, 42 (17.6%) experienced virological rebound by 96 weeks. Both self-reported non-adherence and sub-optimal concentration were independently associated with a higher risk of virological rebound.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalAntiviral Therapy
Volume9
Issue number2
Publication statusPublished - Apr 2004

ASJC Scopus subject areas

  • Pharmacology

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