Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART

Andrea Antinori, Alessandro Cozzi-Lepri, Adriana Ammassari, Maria Paola Trotta, David Nauwelaers, Richard Hoetelmans, Rita Murri, Sara Melzi, Pasquale Narciso, Paola Nasta, Mauro Zaccarelli, Paola Santopadre, Jacopo Vecchiet, Crescenzo Maria Izzo, Antonella D'Arminio Monforte

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Abstract

We studied the predictive value of self-reported adherence and plasma drug concentrations on virological rebound to HAART. Among 238 participants in the AdICoNA study who had viral load ≤500 copies/ml, 42 (17.6%) experienced virological rebound by 96 weeks. Both self-reported non-adherence and sub-optimal concentration were independently associated with a higher risk of virological rebound.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalAntiviral Therapy
Volume9
Issue number2
Publication statusPublished - Apr 2004

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Antinori, A., Cozzi-Lepri, A., Ammassari, A., Trotta, M. P., Nauwelaers, D., Hoetelmans, R., Murri, R., Melzi, S., Narciso, P., Nasta, P., Zaccarelli, M., Santopadre, P., Vecchiet, J., Izzo, C. M., & D'Arminio Monforte, A. (2004). Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART. Antiviral Therapy, 9(2), 291-296.