RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?

Elisa Masat, Chiara Gasparini, Chiara Agostinis, Fleur Bossi, Oriano Radillo, Francesco De Seta, Nicola Tamassia, Marco A. Cassatella, Roberta Bulla

Research output: Contribution to journalArticlepeer-review

Abstract

It is known that excessive inflammation at fetal-maternal interface is a key contributor in a compromised pregnancy. Female genital tract is constantly in contact with microorganisms and several strategies must be adopted to avoid pregnancy failure. Decidual endothelial cells (DECs) lining decidual microvascular vessels are the first cells that interact with pro-inflammatory stimuli released into the environment by microorganisms derived from gestational tissues or systemic circulation. Here, we show that DECs are hypo-responsive to LPS stimulation in terms of IL-6, CXCL8 and CCL2 production. Our results demonstrate that DECs express low levels of TLR4 and are characterized by a strong constitutive activation of the non-canonical NF-? B pathway and a low responsiveness of the canonical pathway to LPS. In conclusion, DECs show a unique hypo-responsive phenotype to the pro-inflammatory stimulus LPS in order to control the inflammatory response at feto-maternal interface.

Original languageEnglish
Article number14847
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Oct 14 2015

ASJC Scopus subject areas

  • General

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