Release of growth factors after arthroscopic acromioplasty

Pietro Randelli, Fabrizio Margheritini, Paolo Cabitza, Giada Dogliotti, Massimiliano M. Corsi

Research output: Contribution to journalArticlepeer-review


It has recently been postulated that a variety of growth factors may be released from cancellous bone after an acromioplasty. The aim of this study was to demonstrate the presence of growth factors in the subacromial space after acromioplasty. Between October 2006 and March 2007, 23 patients underwent arthroscopic acromioplasty. A sample of at least 3 ml of fluid from the shoulder was obtained 15 min after the end of the procedure. At the same time another sample of 3 ml of the patient's venous blood was obtained as a control. The concentrations of growth factors in the fluids collected were determined using enzyme-linked immunosorbent assay (ELISA). The growth factors assayed were platelet-derived growth factor-AB (PDGF-AB), basic fibroblast growth factor basic (bFGF) and transforming growth factor beta 1 (TGF-β1). The concentrations of TGF-β1 (p = 0.0001), PDGF-AB (p = 0.02), and bFGF (p <0.0001) were significantly higher in the fluid from the subacromial space than in the blood sample. There are high concentrations of several growth factors in the subacromial space after acromioplasty.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Issue number1
Publication statusPublished - Jan 2009


  • Acromioplasty
  • Arthroscopy
  • Cuff disease
  • Growth factors
  • Tendon healing

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery


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