Release of Met-enkephalin from rat striatal slices: effect of amphetamine and fipexide

Laura Lucchi, Stefano Govoni, Pier Franco Spano, Marco Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.

Original languageEnglish
Pages (from-to)212-214
Number of pages3
JournalBrain Research
Volume398
Issue number1
DOIs
Publication statusPublished - Nov 19 1986

Keywords

  • Amphetamine
  • Fipexide
  • Met-enkephalin release
  • Striatal slice

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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