Abstract
The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.
Original language | English |
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Pages (from-to) | 212-214 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 398 |
Issue number | 1 |
DOIs | |
Publication status | Published - Nov 19 1986 |
Keywords
- Amphetamine
- Fipexide
- Met-enkephalin release
- Striatal slice
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)