Release of Met-enkephalin from rat striatal slices: effect of amphetamine and fipexide

Laura Lucchi; Stefano Govoni; Pier Franco Spano; Marco Trabucchi

doi:10.1016/0006-8993(86)91273-4

Release of Met-enkephalin from rat striatal slices: effect of amphetamine and fipexide

Laura Lucchi, Stefano Govoni, Pier Franco Spano, Marco Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.

Original language	English
Pages (from-to)	212-214
Number of pages	3
Journal	Brain Research
Volume	398
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91273-4
Publication status	Published - Nov 19 1986

Keywords

Amphetamine
Fipexide
Met-enkephalin release
Striatal slice

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

Access to Document

10.1016/0006-8993(86)91273-4

Cite this

@article{76b5f0cc28ac4003b742bf5983ece437,

title = "Release of Met-enkephalin from rat striatal slices: effect of amphetamine and fipexide",

abstract = "The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.",

keywords = "Amphetamine, Fipexide, Met-enkephalin release, Striatal slice",

author = "Laura Lucchi and Stefano Govoni and Spano, {Pier Franco} and Marco Trabucchi",

year = "1986",

month = nov,

day = "19",

doi = "10.1016/0006-8993(86)91273-4",

language = "English",

volume = "398",

pages = "212--214",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Release of Met-enkephalin from rat striatal slices

T2 - effect of amphetamine and fipexide

AU - Lucchi, Laura

AU - Govoni, Stefano

AU - Spano, Pier Franco

AU - Trabucchi, Marco

PY - 1986/11/19

Y1 - 1986/11/19

N2 - The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.

AB - The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.

KW - Amphetamine

KW - Fipexide

KW - Met-enkephalin release

KW - Striatal slice

UR - http://www.scopus.com/inward/record.url?scp=0023010425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023010425&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)91273-4

DO - 10.1016/0006-8993(86)91273-4

M3 - Article

C2 - 2879607

AN - SCOPUS:0023010425

VL - 398

SP - 212

EP - 214

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Release of Met-enkephalin from rat striatal slices: effect of amphetamine and fipexide

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this