Abstract
The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.
| Original language | English |
|---|---|
| Pages (from-to) | 212-214 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 398 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 19 1986 |
Fingerprint
Keywords
- Amphetamine
- Fipexide
- Met-enkephalin release
- Striatal slice
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Release of Met-enkephalin from rat striatal slices : effect of amphetamine and fipexide. / Lucchi, Laura; Govoni, Stefano; Spano, Pier Franco; Trabucchi, Marco.
In: Brain Research, Vol. 398, No. 1, 19.11.1986, p. 212-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Release of Met-enkephalin from rat striatal slices
T2 - effect of amphetamine and fipexide
AU - Lucchi, Laura
AU - Govoni, Stefano
AU - Spano, Pier Franco
AU - Trabucchi, Marco
PY - 1986/11/19
Y1 - 1986/11/19
N2 - The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.
AB - The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dixoy 3,4-benzyl-4-pineperazine) a psychostimulant drug with mild dopaminomimetic activity. Both ampethamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine. pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.
KW - Amphetamine
KW - Fipexide
KW - Met-enkephalin release
KW - Striatal slice
UR - http://www.scopus.com/inward/record.url?scp=0023010425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023010425&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(86)91273-4
DO - 10.1016/0006-8993(86)91273-4
M3 - Article
C2 - 2879607
AN - SCOPUS:0023010425
VL - 398
SP - 212
EP - 214
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -