Abstract
The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.
Original language | English |
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Pages (from-to) | 1896-1898 |
Number of pages | 3 |
Journal | Neurology |
Volume | 52 |
Issue number | 9 |
Publication status | Published - 1999 |
ASJC Scopus subject areas
- Neuroscience(all)