Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients

F. L. Sciacca; C. Ferri; K. Vandenbroeck; F. Veglia; G. Gobbi; F. Martinelli; D. Franciotta; M. Zaffaroni; M. Marrosu; G. Martino; V. Martinelli; G. Comi; N. Canal; L. M E Grimaldi

Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients

F. L. Sciacca, C. Ferri, K. Vandenbroeck, F. Veglia, G. Gobbi, F. Martinelli, D. Franciotta, M. Zaffaroni, M. Marrosu, G. Martino, V. Martinelli, G. Comi, N. Canal, L. M E Grimaldi

Research output: Contribution to journal › Article › peer-review

Abstract

The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1⁺ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1⁺ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.

Original language	English
Pages (from-to)	1896-1898
Number of pages	3
Journal	Neurology
Volume	52
Issue number	9
Publication status	Published - 1999

ASJC Scopus subject areas

Neuroscience(all)

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Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients. / Sciacca, F. L.; Ferri, C.; Vandenbroeck, K.; Veglia, F.; Gobbi, G.; Martinelli, F.; Franciotta, D.; Zaffaroni, M.; Marrosu, M.; Martino, G.; Martinelli, V.; Comi, G.; Canal, N.; Grimaldi, L. M E.

In: Neurology, Vol. 52, No. 9, 1999, p. 1896-1898.

Research output: Contribution to journal › Article › peer-review

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title = "Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients",

abstract = "The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.",

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AU - Sciacca, F. L.

AU - Ferri, C.

AU - Vandenbroeck, K.

AU - Veglia, F.

AU - Gobbi, G.

AU - Martinelli, F.

AU - Franciotta, D.

AU - Zaffaroni, M.

AU - Marrosu, M.

AU - Martino, G.

AU - Martinelli, V.

AU - Comi, G.

AU - Canal, N.

AU - Grimaldi, L. M E

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N2 - The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.

AB - The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.

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JO - Neurology

JF - Neurology

SN - 0028-3878

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Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients

Abstract

ASJC Scopus subject areas

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