Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients

F. L. Sciacca, C. Ferri, K. Vandenbroeck, F. Veglia, G. Gobbi, F. Martinelli, D. Franciotta, M. Zaffaroni, M. Marrosu, G. Martino, V. Martinelli, G. Comi, N. Canal, L. M E Grimaldi

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Abstract

The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.

Original languageEnglish
Pages (from-to)1896-1898
Number of pages3
JournalNeurology
Volume52
Issue number9
Publication statusPublished - 1999

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sciacca, F. L., Ferri, C., Vandenbroeck, K., Veglia, F., Gobbi, G., Martinelli, F., Franciotta, D., Zaffaroni, M., Marrosu, M., Martino, G., Martinelli, V., Comi, G., Canal, N., & Grimaldi, L. M. E. (1999). Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients. Neurology, 52(9), 1896-1898.