Abstract
The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gone polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1896-1898 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 52 |
| Issue number | 9 |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Sciacca, F. L., Ferri, C., Vandenbroeck, K., Veglia, F., Gobbi, G., Martinelli, F., Franciotta, D., Zaffaroni, M., Marrosu, M., Martino, G., Martinelli, V., Comi, G., Canal, N., & Grimaldi, L. M. E. (1999). Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients. Neurology, 52(9), 1896-1898.