Relevance of red cell distribution width (RDW) in the differential diagnosis of microcytic anaemias

B. M. Cesana, A. T. Maiolo, R. Gidiuli, I. Damilano, P. Massaro, E. E. Polli

Research output: Contribution to journalArticle

Abstract

The authors studied the red cell distribution width (RDW) index (obtained by Coulter Counter S Plus IV) in normal subjects and in patients with β-thalassaemia trait and iron deficiency anaemia. Statistics and reference limits for the above three conditions are given. In order to make a differential diagnosis between β-thalassaemia trait and iron deficiency anaemia, linear discriminant analysis was carried out. Global correct classification was 91.5% on four first sample of patients and 88.8% on a subsequent validation sample of microcytic patients. The percent of correct β-thalassaemia trait diagnosis was 94.4% and 86.7% for the first and validation samples respectively. For iron deficiency anaemia correct diagnosis of 86.2% and 90.9% were achieved.

Original languageEnglish
Pages (from-to)141-151
Number of pages11
JournalClinical and Laboratory Haematology
Volume13
Issue number2
Publication statusPublished - 1991

Keywords

  • β-Thalassaemia trait
  • Differential diagnosis
  • Iron deficiency anaemia
  • Red cell distribution width (RDW)
  • Reference limits

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Cesana, B. M., Maiolo, A. T., Gidiuli, R., Damilano, I., Massaro, P., & Polli, E. E. (1991). Relevance of red cell distribution width (RDW) in the differential diagnosis of microcytic anaemias. Clinical and Laboratory Haematology, 13(2), 141-151.