Abstract
BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.
AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.
METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.
RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.
CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.
| Original language | English |
|---|---|
| Journal | Cephalalgia |
| DOIs | |
| Publication status | E-pub ahead of print - May 6 2016 |
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Keywords
- Journal Article
Cite this
Reliability and repeatability of testing visual evoked potential habituation in migraine : A blinded case-control study. / Ambrosini, Anna; Coppola, Gianluca; Iezzi, Ennio; Pierelli, Francesco; Schoenen, Jean.
In: Cephalalgia, 06.05.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reliability and repeatability of testing visual evoked potential habituation in migraine
T2 - A blinded case-control study
AU - Ambrosini, Anna
AU - Coppola, Gianluca
AU - Iezzi, Ennio
AU - Pierelli, Francesco
AU - Schoenen, Jean
N1 - © International Headache Society 2016.
PY - 2016/5/6
Y1 - 2016/5/6
N2 - BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.
AB - BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.
KW - Journal Article
U2 - 10.1177/0333102416648656
DO - 10.1177/0333102416648656
M3 - Article
C2 - 27154996
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
ER -