Reliability and repeatability of testing visual evoked potential habituation in migraine: A blinded case-control study

Anna Ambrosini, Gianluca Coppola, Ennio Iezzi, Francesco Pierelli, Jean Schoenen

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.

AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.

METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.

RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.

CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.

Original languageEnglish
JournalCephalalgia
DOIs
Publication statusE-pub ahead of print - May 6 2016

Keywords

  • Journal Article

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