Reliability and repeatability of testing visual evoked potential habituation in migraine: A blinded case-control study

Anna Ambrosini, Gianluca Coppola, Ennio Iezzi, Francesco Pierelli, Jean Schoenen

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.

AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.

METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.

RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.

CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.

Original languageEnglish
JournalCephalalgia
DOIs
Publication statusE-pub ahead of print - May 6 2016

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Visual Evoked Potentials
Migraine Disorders
Case-Control Studies
Healthy Volunteers
Headache
Stroke
Research Personnel

Keywords

  • Journal Article

Cite this

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title = "Reliability and repeatability of testing visual evoked potential habituation in migraine: A blinded case-control study",
abstract = "BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.",
keywords = "Journal Article",
author = "Anna Ambrosini and Gianluca Coppola and Ennio Iezzi and Francesco Pierelli and Jean Schoenen",
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TY - JOUR

T1 - Reliability and repeatability of testing visual evoked potential habituation in migraine

T2 - A blinded case-control study

AU - Ambrosini, Anna

AU - Coppola, Gianluca

AU - Iezzi, Ennio

AU - Pierelli, Francesco

AU - Schoenen, Jean

N1 - © International Headache Society 2016.

PY - 2016/5/6

Y1 - 2016/5/6

N2 - BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.

AB - BACKGROUND: Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability.AIMS: In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test-retest repeatability.METHODS: VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability.RESULTS: In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days.CONCLUSIONS: The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.

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JO - Cephalalgia

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SN - 0333-1024

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