Abstract
To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.
| Original language | English |
|---|---|
| Pages (from-to) | 699-704 |
| Number of pages | 6 |
| Journal | Movement Disorders |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2006 |
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Keywords
- Clinical assessment
- ICARS
- Spinocerebellar ataxia
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Reliability and validity of the International Cooperative Ataxia Rating Scale : A study in 156 spinocerebellar ataxia patients. / Schmitz-Hübsch, Tanja; du Montcel, Sophie Tezenas; Baliko, Laszlo; Boesch, Sylvia; Bonato, Sara; Fancellu, Roberto; Giunti, Paola; Globas, Christoph; Kang, Jun Suk; Kremer, Berry; Mariotti, Caterina; Melegh, Bela; Rakowicz, Maryla; Rola, Rafal; Romano, Sylvie; Schöls, Lodger; Szymanski, Sandra; van de Warrenburg, Bart P C; Zdzienicka, Elzbieta; Dürr, Alexandra; Klockgether, Thomas.
In: Movement Disorders, Vol. 21, No. 5, 05.2006, p. 699-704.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reliability and validity of the International Cooperative Ataxia Rating Scale
T2 - A study in 156 spinocerebellar ataxia patients
AU - Schmitz-Hübsch, Tanja
AU - du Montcel, Sophie Tezenas
AU - Baliko, Laszlo
AU - Boesch, Sylvia
AU - Bonato, Sara
AU - Fancellu, Roberto
AU - Giunti, Paola
AU - Globas, Christoph
AU - Kang, Jun Suk
AU - Kremer, Berry
AU - Mariotti, Caterina
AU - Melegh, Bela
AU - Rakowicz, Maryla
AU - Rola, Rafal
AU - Romano, Sylvie
AU - Schöls, Lodger
AU - Szymanski, Sandra
AU - van de Warrenburg, Bart P C
AU - Zdzienicka, Elzbieta
AU - Dürr, Alexandra
AU - Klockgether, Thomas
PY - 2006/5
Y1 - 2006/5
N2 - To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.
AB - To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.
KW - Clinical assessment
KW - ICARS
KW - Spinocerebellar ataxia
UR - http://www.scopus.com/inward/record.url?scp=33646918007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646918007&partnerID=8YFLogxK
U2 - 10.1002/mds.20781
DO - 10.1002/mds.20781
M3 - Article
C2 - 16450347
AN - SCOPUS:33646918007
VL - 21
SP - 699
EP - 704
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 5
ER -