Reliability of equations to estimate glomerular filtration rate in the very old

Claudio Pedone, Roberto Semeraro, Domenica Chiurco, Francesco D'Andria, Maurizio Gigante, Anna Coppola, Andrea Corsonello, Raffaele Antonelli-Incalzi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl

Original languageEnglish
Pages (from-to)496-502
Number of pages7
JournalAging clinical and experimental research
Volume20
Issue number6
Publication statusPublished - Dec 2008

Fingerprint

Glomerular Filtration Rate
Creatinine
Diet Therapy
Kidney
Urine Specimen Collection
Renal Insufficiency
Serum

Keywords

  • 80 and over
  • Elderly
  • Estimating equations
  • Kidney function tests

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Pedone, C., Semeraro, R., Chiurco, D., D'Andria, F., Gigante, M., Coppola, A., ... Antonelli-Incalzi, R. (2008). Reliability of equations to estimate glomerular filtration rate in the very old. Aging clinical and experimental research, 20(6), 496-502.

Reliability of equations to estimate glomerular filtration rate in the very old. / Pedone, Claudio; Semeraro, Roberto; Chiurco, Domenica; D'Andria, Francesco; Gigante, Maurizio; Coppola, Anna; Corsonello, Andrea; Antonelli-Incalzi, Raffaele.

In: Aging clinical and experimental research, Vol. 20, No. 6, 12.2008, p. 496-502.

Research output: Contribution to journalArticle

Pedone, C, Semeraro, R, Chiurco, D, D'Andria, F, Gigante, M, Coppola, A, Corsonello, A & Antonelli-Incalzi, R 2008, 'Reliability of equations to estimate glomerular filtration rate in the very old', Aging clinical and experimental research, vol. 20, no. 6, pp. 496-502.
Pedone C, Semeraro R, Chiurco D, D'Andria F, Gigante M, Coppola A et al. Reliability of equations to estimate glomerular filtration rate in the very old. Aging clinical and experimental research. 2008 Dec;20(6):496-502.
Pedone, Claudio ; Semeraro, Roberto ; Chiurco, Domenica ; D'Andria, Francesco ; Gigante, Maurizio ; Coppola, Anna ; Corsonello, Andrea ; Antonelli-Incalzi, Raffaele. / Reliability of equations to estimate glomerular filtration rate in the very old. In: Aging clinical and experimental research. 2008 ; Vol. 20, No. 6. pp. 496-502.
@article{443377004aec468797fac6f83d688ec5,
title = "Reliability of equations to estimate glomerular filtration rate in the very old",
abstract = "Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaff{\'e} method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95{\%} agreement intervals (95{\%} AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95{\%} AI showed that all formulas can yield results as low as 50{\%} or as high as 200{\%} of measured CrCl. The proportion of people with CrCl",
keywords = "80 and over, Elderly, Estimating equations, Kidney function tests",
author = "Claudio Pedone and Roberto Semeraro and Domenica Chiurco and Francesco D'Andria and Maurizio Gigante and Anna Coppola and Andrea Corsonello and Raffaele Antonelli-Incalzi",
year = "2008",
month = "12",
language = "English",
volume = "20",
pages = "496--502",
journal = "Aging clinical and experimental research",
issn = "1594-0667",
publisher = "Springer International Publishing AG",
number = "6",

}

TY - JOUR

T1 - Reliability of equations to estimate glomerular filtration rate in the very old

AU - Pedone, Claudio

AU - Semeraro, Roberto

AU - Chiurco, Domenica

AU - D'Andria, Francesco

AU - Gigante, Maurizio

AU - Coppola, Anna

AU - Corsonello, Andrea

AU - Antonelli-Incalzi, Raffaele

PY - 2008/12

Y1 - 2008/12

N2 - Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl

AB - Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl

KW - 80 and over

KW - Elderly

KW - Estimating equations

KW - Kidney function tests

UR - http://www.scopus.com/inward/record.url?scp=60749124912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60749124912&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 496

EP - 502

JO - Aging clinical and experimental research

JF - Aging clinical and experimental research

SN - 1594-0667

IS - 6

ER -