Reliability of equations to estimate glomerular filtration rate in the very old

Claudio Pedone, Roberto Semeraro, Domenica Chiurco, Francesco D'Andria, Maurizio Gigante, Anna Coppola, Andrea Corsonello, Raffaele Antonelli-Incalzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl

Original languageEnglish
Pages (from-to)496-502
Number of pages7
JournalAging clinical and experimental research
Volume20
Issue number6
Publication statusPublished - Dec 2008

Keywords

  • 80 and over
  • Elderly
  • Estimating equations
  • Kidney function tests

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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