Abstract
Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl
| Original language | English |
|---|---|
| Pages (from-to) | 496-502 |
| Number of pages | 7 |
| Journal | Aging clinical and experimental research |
| Volume | 20 |
| Issue number | 6 |
| Publication status | Published - Dec 2008 |
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Keywords
- 80 and over
- Elderly
- Estimating equations
- Kidney function tests
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Reliability of equations to estimate glomerular filtration rate in the very old. / Pedone, Claudio; Semeraro, Roberto; Chiurco, Domenica; D'Andria, Francesco; Gigante, Maurizio; Coppola, Anna; Corsonello, Andrea; Antonelli-Incalzi, Raffaele.
In: Aging clinical and experimental research, Vol. 20, No. 6, 12.2008, p. 496-502.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reliability of equations to estimate glomerular filtration rate in the very old
AU - Pedone, Claudio
AU - Semeraro, Roberto
AU - Chiurco, Domenica
AU - D'Andria, Francesco
AU - Gigante, Maurizio
AU - Coppola, Anna
AU - Corsonello, Andrea
AU - Antonelli-Incalzi, Raffaele
PY - 2008/12
Y1 - 2008/12
N2 - Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl
AB - Background and aims: Few studies have investigated the reliability of formulas estimating renal function in very old people. Methods: We studied 154 elderly people (mean age: 82 yrs). Serum creatinine (SC) was measured by the Jaffé method, and creatinine clearance (CrCl) with 24-h urine collection. Agreement was measured with the average ratio estimated/measured CrCl, and precision with the 95% agreement intervals (95% AI). We calculated the proportion of residents correctly classified as having renal insufficiency (accuracy). Results: The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease 1 (MDRD1) formulas showed good average agreement with measured CrCl (0.95 and 1.016, respectively); the MDRD2 formula was more biased. Results were consistent in women, whereas the MDRD1 was more biased in men (average ratio: 1.196). The 95% AI showed that all formulas can yield results as low as 50% or as high as 200% of measured CrCl. The proportion of people with CrCl
KW - 80 and over
KW - Elderly
KW - Estimating equations
KW - Kidney function tests
UR - http://www.scopus.com/inward/record.url?scp=60749124912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60749124912&partnerID=8YFLogxK
M3 - Article
VL - 20
SP - 496
EP - 502
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
IS - 6
ER -