Reliability of MRI-derived measurements of human cerebral cortical thickness: The effects of field strength, scanner upgrade and manufacturer

Xiao Han, Jorge Jovicich, David Salat, Andre van der Kouwe, Brian Quinn, Silvester Czanner, Evelina Busa, Jenni Pacheco, Marilyn Albert, Ronald Killiany, Paul Maguire, Diana Rosas, Nikos Makris, Anders Dale, Bradford Dickerson, Bruce Fischl

Research output: Contribution to journalArticle

Abstract

In vivo MRI-derived measurements of human cerebral cortex thickness are providing novel insights into normal and abnormal neuroanatomy, but little is known about their reliability. We investigated how the reliability of cortical thickness measurements is affected by MRI instrument-related factors, including scanner field strength, manufacturer, upgrade and pulse sequence. Several data processing factors were also studied. Two test -retest data sets were analyzed: 1) 15 healthy older subjects scanned four times at 2-week intervals on three scanners; 2) 5 subjects scanned before and after a major scanner upgrade. Within-scanner variability of global cortical thickness measurements was

Original languageEnglish
Pages (from-to)180-194
Number of pages15
JournalNeuroImage
Volume32
Issue number1
DOIs
Publication statusPublished - 2006

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Keywords

  • Cerebral cortex
  • Cortical thickness
  • Morphology
  • Structural MRI

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Han, X., Jovicich, J., Salat, D., van der Kouwe, A., Quinn, B., Czanner, S., Busa, E., Pacheco, J., Albert, M., Killiany, R., Maguire, P., Rosas, D., Makris, N., Dale, A., Dickerson, B., & Fischl, B. (2006). Reliability of MRI-derived measurements of human cerebral cortical thickness: The effects of field strength, scanner upgrade and manufacturer. NeuroImage, 32(1), 180-194. https://doi.org/10.1016/j.neuroimage.2006.02.051