Reliability of pancreatic cancer staging classifications

Alessandro Zerbi, Gianpaolo Balzano, Roberto Bottura, Valerio DiCarlo

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic value of UICC and JPS classifications was evaluated in a group of 74 patients undergoing resection for pancreatic carcinoma in the 1982-1992 period. The predictivity of peritoneal cytology and intraoperative liver biopsies was evaluated in a subgroup of 15 patients. Patient division by stage according, respectively, to UICC and JPS classifications was: stage I: 28 and 2 patients; stage II: 12 and 11 patients; stage III: 29 and 30 patients; stage IV: 5 and 31 patients. Median survival by UICC stages was: 17 months (m) in stage I, 10 m in stage II, 12 m in stage III, and 6 m in stage IV; by JPS stages it was 29 m in stage II, 14 m in stage III, and 7 m in stage IV. A radical resection was possible in 48 patients (65%); the survival was significantly worse in the nonradical resection group. The survival difference among UICC stages was not significant in a multivariate analysis with radicality, whereas among JPS stages a significant survival difference was found in both univariate and multivariate analysis. The tumor invasion of the retroperitoneal tissues and the presence of distant metastasis were indicators of a significantly worse prognosis. Lymph node involvement, tumor size, and serosal invasion had no significant effect on survival. Peritoneal cytology and liver biopsies did not provide further prognostic information.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalInternational Journal of Pancreatology
Volume15
Issue number1
DOIs
Publication statusPublished - Feb 1994

Keywords

  • hepatic biopsy
  • Japanese stage classification
  • Pancreatic cancer
  • pancreatic resection
  • peritoneal cytology
  • UICC stage classification

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

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