Reliability of procalcitonin in neonatology. Experience in 59 preterm newborns

Serena Spada, Antonella Cuccu, Michele Mussap, Marcella Testa, Melania Puddu, Cinzia Pisu, Pietrina Burrai, Vassilios Fanos

Research output: Contribution to journalArticlepeer-review


Procalcitonin PCT has been proposed as an interesting marker in the diagnosis, prognosis, and response to treatment of patient with neonatal sepsis. Fifty-nine neonates 34 males and 25 females with a mean gestational age of ∼31 weeks and a mean weight of about 1750 g admitted in the Neonatal Intensive Care Unit of Cagliari Italy were evaluated in controls and in infected neonates, before and after 48 h of life. From our experience it emerges that PCT is a marker of early and late neonatal sepsis which is reliable in preterm neonates. A cut-off of 0.5 ngml starting from the third day of life appears to be capable of ensuring good test sensitivity and specificity.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue numberSUPPL. 3
Publication statusPublished - 2009


  • Acute-phase markers
  • Infection
  • Neonatal sepsis
  • Preterm newborns
  • Procalcitonin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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