Reliability of radioactive inulin as a marker of glomerular filtration rate in the rat

Vittorio E. Andreucci, Antonio Dal Canton, Ariberto Corradi, Carla Gherardi

Research output: Contribution to journalArticlepeer-review

Abstract

Clearance experiments were carried out in rats for evaluating the reliability of Inulin-Methoxy-H3 as marker for GFR determination. When H3 Inulin clearance was compared with C14 Polyethylen Glycol (PEG) 1000 clearance, a linear relationship was observed (y=0.021+0.867 x;r=0.98). H3 Inulin clearance/C14 PEG clearance ratio was 0.88±0.09 (S.D.), i.e. a value no different from those reported in literature for unlabeled Inulin, C14 Inulin and Polyfructosan S. Several types of scintillation solution were tested to evaluate the stability with time of count rate of radioactive Inulin. A perfect reproducibility with time was observed in the clearance values in the kidney as a whole (GFR) and in single nephrons (SNGFR) with the following scintillators: Triton X 100-Toluene-PPO, Aquasol and Instagel. Useful suggestions on the way of using labeled Inulin are given.

Original languageEnglish
Pages (from-to)347-358
Number of pages12
JournalPflugers Archiv European Journal of Physiology
Volume350
Issue number4
DOIs
Publication statusPublished - Dec 1974

Keywords

  • C Polyethylen Glycol 1000
  • Inulin-Carboxyl-C
  • Inulin-Methoxy-H
  • Scintillation Solution
  • Single Nephron Glomerular Filtration Rate

ASJC Scopus subject areas

  • Physiology

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