Reliability of urinary 6-sulfatoxymelatonin as a biomarker in breast cancer

M. Barba, A. Cavalleri, H. J. Schünemann, V. Krogh, A. Evangelista, G. Secreto, A. Micheli, Q. Zhou, B. Fuhrman, B. Teter, F. Berrino, Paola Muti

Research output: Contribution to journalArticlepeer-review


The objective of this study is to evaluate the effect of cryopreservation at different storage temperatures on urinary 6-sulfatoxymelatonin (aMT6s) concentration. Overnight urine from 28 postmenopausal women participating in the ORDET cohort study was filtered and separated into 6 mL aliquots. Urine samples were stored at -80°C and at -30°C for an average of 14 years. Urinary aMT6s concentration was assessed using a competitive immunoassay. Mean aMT6s values of samples stored at -30°C were systematically lower than those of samples stored at -80°C (10.7 ng/mL versus 15.8 ng/mL, p

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalInternational Journal of Biological Markers
Issue number4
Publication statusPublished - Oct 2006


  • 6-Sulfatoxymelatonin
  • Biomarker
  • Breast cancer
  • Cryopreservation
  • Storage temperature

ASJC Scopus subject areas

  • Immunology
  • Biochemistry


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