Reliability of urinary 6-sulfatoxymelatonin as a biomarker in breast cancer

M. Barba; A. Cavalleri; H. J. Schünemann; V. Krogh; A. Evangelista; G. Secreto; A. Micheli; Q. Zhou; B. Fuhrman; B. Teter; F. Berrino; Paola Muti

Reliability of urinary 6-sulfatoxymelatonin as a biomarker in breast cancer

M. Barba, A. Cavalleri, H. J. Schünemann, V. Krogh, A. Evangelista, G. Secreto, A. Micheli, Q. Zhou, B. Fuhrman, B. Teter, F. Berrino, Paola Muti

Research output: Contribution to journal › Article › peer-review

Abstract

The objective of this study is to evaluate the effect of cryopreservation at different storage temperatures on urinary 6-sulfatoxymelatonin (aMT6s) concentration. Overnight urine from 28 postmenopausal women participating in the ORDET cohort study was filtered and separated into 6 mL aliquots. Urine samples were stored at -80°C and at -30°C for an average of 14 years. Urinary aMT6s concentration was assessed using a competitive immunoassay. Mean aMT6s values of samples stored at -30°C were systematically lower than those of samples stored at -80°C (10.7 ng/mL versus 15.8 ng/mL, p

Original language	English
Pages (from-to)	242-245
Number of pages	4
Journal	International Journal of Biological Markers
Volume	21
Issue number	4
Publication status	Published - Oct 2006

Keywords

6-Sulfatoxymelatonin
Biomarker
Breast cancer
Cryopreservation
Storage temperature

ASJC Scopus subject areas

Immunology
Biochemistry

Cite this

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title = "Reliability of urinary 6-sulfatoxymelatonin as a biomarker in breast cancer",

abstract = "The objective of this study is to evaluate the effect of cryopreservation at different storage temperatures on urinary 6-sulfatoxymelatonin (aMT6s) concentration. Overnight urine from 28 postmenopausal women participating in the ORDET cohort study was filtered and separated into 6 mL aliquots. Urine samples were stored at -80°C and at -30°C for an average of 14 years. Urinary aMT6s concentration was assessed using a competitive immunoassay. Mean aMT6s values of samples stored at -30°C were systematically lower than those of samples stored at -80°C (10.7 ng/mL versus 15.8 ng/mL, p",

keywords = "6-Sulfatoxymelatonin, Biomarker, Breast cancer, Cryopreservation, Storage temperature",

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AU - Barba, M.

AU - Cavalleri, A.

AU - Schünemann, H. J.

AU - Krogh, V.

AU - Evangelista, A.

AU - Secreto, G.

AU - Micheli, A.

AU - Zhou, Q.

AU - Fuhrman, B.

AU - Teter, B.

AU - Berrino, F.

AU - Muti, Paola

PY - 2006/10

Y1 - 2006/10

N2 - The objective of this study is to evaluate the effect of cryopreservation at different storage temperatures on urinary 6-sulfatoxymelatonin (aMT6s) concentration. Overnight urine from 28 postmenopausal women participating in the ORDET cohort study was filtered and separated into 6 mL aliquots. Urine samples were stored at -80°C and at -30°C for an average of 14 years. Urinary aMT6s concentration was assessed using a competitive immunoassay. Mean aMT6s values of samples stored at -30°C were systematically lower than those of samples stored at -80°C (10.7 ng/mL versus 15.8 ng/mL, p

AB - The objective of this study is to evaluate the effect of cryopreservation at different storage temperatures on urinary 6-sulfatoxymelatonin (aMT6s) concentration. Overnight urine from 28 postmenopausal women participating in the ORDET cohort study was filtered and separated into 6 mL aliquots. Urine samples were stored at -80°C and at -30°C for an average of 14 years. Urinary aMT6s concentration was assessed using a competitive immunoassay. Mean aMT6s values of samples stored at -30°C were systematically lower than those of samples stored at -80°C (10.7 ng/mL versus 15.8 ng/mL, p

KW - 6-Sulfatoxymelatonin

KW - Biomarker

KW - Breast cancer

KW - Cryopreservation

KW - Storage temperature

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Reliability of urinary 6-sulfatoxymelatonin as a biomarker in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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