REM sleep behaviour disorder

Luigi Ferini-Strambi, M. L. Fantini, M. Zucconi, V. Castronovo, S. Marelli, A. Oldani, S. Cappa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

REM sleep behaviour disorder (RBD) is a parasomnia characterised by nocturnal complex motor activity associated with dream mentation. RBD, which affects mainly older men, may be idiopathic or associated with other neurological disorders. A strong association between RBD and alpha-synucleinopathies has been recently observed, with the parasomnia often heralding the clinical onset of the neurodegenerative disease. The idiopathic form accounts for up to 60% of the cases reported in the three largest series of RBD patients. Follow-up studies in small samples revealed that a proportion of RBD patients will eventually develop Parkinson's disease and/or a dementia of Lewy bodies type in the years following the RBD diagnosis. Recently, neurophysiological and neuropsychological studies in idiopathic RBD have found evidence of central nervous system dysfunction. An impairment of cortical activity, specific neuropsychological deficits, signs of autonomic dysfunction and olfactory impairment have been observed in these patients, challenging the concept of idiopathic RBD. The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies.

Original languageEnglish
JournalNeurological Sciences
Volume26
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Dec 2005

Fingerprint

REM Sleep Behavior Disorder
Parasomnias
Neurodegenerative Diseases
Somatotypes
Nervous System Diseases
Parkinson Disease
Dementia
Motor Activity
Central Nervous System
Prospective Studies

Keywords

  • Parasomnia
  • RBD
  • REM sleep

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Ferini-Strambi, L., Fantini, M. L., Zucconi, M., Castronovo, V., Marelli, S., Oldani, A., & Cappa, S. (2005). REM sleep behaviour disorder. Neurological Sciences, 26(SUPPL. 3). https://doi.org/10.1007/s10072-005-0485-7

REM sleep behaviour disorder. / Ferini-Strambi, Luigi; Fantini, M. L.; Zucconi, M.; Castronovo, V.; Marelli, S.; Oldani, A.; Cappa, S.

In: Neurological Sciences, Vol. 26, No. SUPPL. 3, 12.2005.

Research output: Contribution to journalArticle

Ferini-Strambi, L, Fantini, ML, Zucconi, M, Castronovo, V, Marelli, S, Oldani, A & Cappa, S 2005, 'REM sleep behaviour disorder', Neurological Sciences, vol. 26, no. SUPPL. 3. https://doi.org/10.1007/s10072-005-0485-7
Ferini-Strambi L, Fantini ML, Zucconi M, Castronovo V, Marelli S, Oldani A et al. REM sleep behaviour disorder. Neurological Sciences. 2005 Dec;26(SUPPL. 3). https://doi.org/10.1007/s10072-005-0485-7
Ferini-Strambi, Luigi ; Fantini, M. L. ; Zucconi, M. ; Castronovo, V. ; Marelli, S. ; Oldani, A. ; Cappa, S. / REM sleep behaviour disorder. In: Neurological Sciences. 2005 ; Vol. 26, No. SUPPL. 3.
@article{8ab5a13b059c4b75ad74b40a8971aeb1,
title = "REM sleep behaviour disorder",
abstract = "REM sleep behaviour disorder (RBD) is a parasomnia characterised by nocturnal complex motor activity associated with dream mentation. RBD, which affects mainly older men, may be idiopathic or associated with other neurological disorders. A strong association between RBD and alpha-synucleinopathies has been recently observed, with the parasomnia often heralding the clinical onset of the neurodegenerative disease. The idiopathic form accounts for up to 60{\%} of the cases reported in the three largest series of RBD patients. Follow-up studies in small samples revealed that a proportion of RBD patients will eventually develop Parkinson's disease and/or a dementia of Lewy bodies type in the years following the RBD diagnosis. Recently, neurophysiological and neuropsychological studies in idiopathic RBD have found evidence of central nervous system dysfunction. An impairment of cortical activity, specific neuropsychological deficits, signs of autonomic dysfunction and olfactory impairment have been observed in these patients, challenging the concept of idiopathic RBD. The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies.",
keywords = "Parasomnia, RBD, REM sleep",
author = "Luigi Ferini-Strambi and Fantini, {M. L.} and M. Zucconi and V. Castronovo and S. Marelli and A. Oldani and S. Cappa",
year = "2005",
month = "12",
doi = "10.1007/s10072-005-0485-7",
language = "English",
volume = "26",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "SUPPL. 3",

}

TY - JOUR

T1 - REM sleep behaviour disorder

AU - Ferini-Strambi, Luigi

AU - Fantini, M. L.

AU - Zucconi, M.

AU - Castronovo, V.

AU - Marelli, S.

AU - Oldani, A.

AU - Cappa, S.

PY - 2005/12

Y1 - 2005/12

N2 - REM sleep behaviour disorder (RBD) is a parasomnia characterised by nocturnal complex motor activity associated with dream mentation. RBD, which affects mainly older men, may be idiopathic or associated with other neurological disorders. A strong association between RBD and alpha-synucleinopathies has been recently observed, with the parasomnia often heralding the clinical onset of the neurodegenerative disease. The idiopathic form accounts for up to 60% of the cases reported in the three largest series of RBD patients. Follow-up studies in small samples revealed that a proportion of RBD patients will eventually develop Parkinson's disease and/or a dementia of Lewy bodies type in the years following the RBD diagnosis. Recently, neurophysiological and neuropsychological studies in idiopathic RBD have found evidence of central nervous system dysfunction. An impairment of cortical activity, specific neuropsychological deficits, signs of autonomic dysfunction and olfactory impairment have been observed in these patients, challenging the concept of idiopathic RBD. The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies.

AB - REM sleep behaviour disorder (RBD) is a parasomnia characterised by nocturnal complex motor activity associated with dream mentation. RBD, which affects mainly older men, may be idiopathic or associated with other neurological disorders. A strong association between RBD and alpha-synucleinopathies has been recently observed, with the parasomnia often heralding the clinical onset of the neurodegenerative disease. The idiopathic form accounts for up to 60% of the cases reported in the three largest series of RBD patients. Follow-up studies in small samples revealed that a proportion of RBD patients will eventually develop Parkinson's disease and/or a dementia of Lewy bodies type in the years following the RBD diagnosis. Recently, neurophysiological and neuropsychological studies in idiopathic RBD have found evidence of central nervous system dysfunction. An impairment of cortical activity, specific neuropsychological deficits, signs of autonomic dysfunction and olfactory impairment have been observed in these patients, challenging the concept of idiopathic RBD. The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies.

KW - Parasomnia

KW - RBD

KW - REM sleep

UR - http://www.scopus.com/inward/record.url?scp=33645746652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645746652&partnerID=8YFLogxK

U2 - 10.1007/s10072-005-0485-7

DO - 10.1007/s10072-005-0485-7

M3 - Article

VL - 26

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - SUPPL. 3

ER -