REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects

Research output: Contribution to journalArticlepeer-review

Abstract

Study Objectives: We aimed to analyze quantitatively REM sleep EEG in controls, drug-naïve idiopathic REM sleep behavior disorder patients (iRBD), and iRBD patients treated with clonazepam. Methods: Twenty-nine drug-naïve iRBD patients (mean age 68.2 years), 14 iRBD patients under chronic clonazepam therapy (mean age 66.3 years) and 21 controls (mean age 66.8 years) were recruited. Power spectra were obtained from sleep EEG (central derivation), using a 2-second sliding window, with 1-second steps. The power values of each REM sleep EEG spectral band (one every second) were normalized with respect to the average power value obtained during sleep stage 2 in the same individual. Results: In drug-naïve patients, the normalized power values showed a less pronounced REM-related decrease of power in all bands with frequency
Original languageEnglish
Article numberzsx080
JournalSleep
Volume40
Issue number8
DOIs
Publication statusPublished - 2017

Fingerprint Dive into the research topics of 'REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects'. Together they form a unique fingerprint.

Cite this