Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery

M. Gemma, C. Tommasino, S. Cozzi, S. Narcisi, P. Mortini, M. Losa, A. Soldarini

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Abstract

In this prospective study, we evaluated the effects of remifentanil in ASA I-II patients undergoing transsphenoidal surgery. After the induction of anesthesia, patients were randomly allocated to the Isoflurane (n = 22, 60% nitrous oxide, isoflurane up to 2% end-tidal) or Remifentanil group (n = 21, 60% nitrous oxide, 0.5% end-tidal isoflurane, remifentanil up to 2 μg·kg-1·min-1. If mean arterial pressure (MAP) increased >80 mm Hg during maximal dosage of isoflurane or remifentanil, labetalol was administered. At the end of anesthesia, extubation and awakening times, respiratory rate, Spo2, MAP, heart rate, and adverse effects were recorded. Hemodynamics and bleeding (minimal, mild, moderate, severe) were not different between groups. Bleeding grade increased with MAP >80 mm Hg (P <0.001). Labetalol was administered to 20 patients in the Isoflurane group, and 10 patients in the Remifentanil group (P <0.01). The dose of labetalol was larger in the Isoflurane group (1.0 ± 0.6 versus 0.5 ± 0.7 mg/kg, P <0.05). Time to extubation did not differ, whereas time to follow commands was shorter in Remifentanil patients (16 ± 8 versus 10 ± 2 min, P <0.01). No adverse effects occurred in the early postoperative period.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalAnesthesia and Analgesia
Volume94
Issue number1
Publication statusPublished - 2002

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Isoflurane
Hemodynamics
Labetalol
Arterial Pressure
Nitrous Oxide
Anesthesia
Hemorrhage
Respiratory Rate
Postoperative Period
remifentanil
Heart Rate
Prospective Studies

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery. / Gemma, M.; Tommasino, C.; Cozzi, S.; Narcisi, S.; Mortini, P.; Losa, M.; Soldarini, A.

In: Anesthesia and Analgesia, Vol. 94, No. 1, 2002, p. 163-168.

Research output: Contribution to journalArticle

Gemma, M. ; Tommasino, C. ; Cozzi, S. ; Narcisi, S. ; Mortini, P. ; Losa, M. ; Soldarini, A. / Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery. In: Anesthesia and Analgesia. 2002 ; Vol. 94, No. 1. pp. 163-168.
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