Remission achieved in chronic nephropathy by a multidrug approach targeted at urinary protein excretion

Piero Ruggenenti, Barry M. Brenner, Giuseppe Remuzzi

Research output: Contribution to journalArticle

Abstract

Regardless of the pattern of renal involvement, increased urinary protein excretion rate is the best independent predictor of progression of chronic nephropathies and short-term reduction in proteinuria has been reported to be renoprotective in the long term. Despite such evidence, however, the therapeutic target in renoprotection is almost exclusively on blood pressure control. We report the clinical course of a patient with chronic nephropathy after the institution of a multidrug treatment titrated against urinary protein excretion to achieve renoprotection. The present findings indicate that adjusting renoprotective therapy according to the decline in protein excretion in a multidrug strategy may stabilize or even reverse renal disease progression. This approach should be formally explored in prospective studies.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalNephron
Volume88
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Chronic nephropathy
  • Multidrug approach
  • Remission
  • Urinary protein excretion

ASJC Scopus subject areas

  • Nephrology

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