Remission of infantile generalized myofibromatosis after interferon alpha therapy

Cinzia Auriti, Mark W. Kieran, Giovanni Deb, Rita Devito, Luciano Pasquini, Olivier Danhaive

Research output: Contribution to journalArticle

Abstract

Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Angiogenesis
  • Basic fibroblast growth factor
  • Interferon alpha-2b
  • Vascular endothelial growth factor
  • Visceral myofibroma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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