Abstract
Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
Original language | English |
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Pages (from-to) | 179-181 |
Number of pages | 3 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 30 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2008 |
Keywords
- Angiogenesis
- Basic fibroblast growth factor
- Interferon alpha-2b
- Vascular endothelial growth factor
- Visceral myofibroma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Hematology