Abstract
Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
| Original language | English |
|---|---|
| Pages (from-to) | 179-181 |
| Number of pages | 3 |
| Journal | Journal of Pediatric Hematology/Oncology |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2008 |
Fingerprint
Keywords
- Angiogenesis
- Basic fibroblast growth factor
- Interferon alpha-2b
- Vascular endothelial growth factor
- Visceral myofibroma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Hematology
Cite this
Remission of infantile generalized myofibromatosis after interferon alpha therapy. / Auriti, Cinzia; Kieran, Mark W.; Deb, Giovanni; Devito, Rita; Pasquini, Luciano; Danhaive, Olivier.
In: Journal of Pediatric Hematology/Oncology, Vol. 30, No. 2, 02.2008, p. 179-181.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Remission of infantile generalized myofibromatosis after interferon alpha therapy
AU - Auriti, Cinzia
AU - Kieran, Mark W.
AU - Deb, Giovanni
AU - Devito, Rita
AU - Pasquini, Luciano
AU - Danhaive, Olivier
PY - 2008/2
Y1 - 2008/2
N2 - Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
AB - Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
KW - Angiogenesis
KW - Basic fibroblast growth factor
KW - Interferon alpha-2b
KW - Vascular endothelial growth factor
KW - Visceral myofibroma
UR - http://www.scopus.com/inward/record.url?scp=41949101467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41949101467&partnerID=8YFLogxK
U2 - 10.1097/MPH.0b013e31815e62bb
DO - 10.1097/MPH.0b013e31815e62bb
M3 - Article
C2 - 18376275
AN - SCOPUS:41949101467
VL - 30
SP - 179
EP - 181
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 2
ER -