Remission of infantile generalized myofibromatosis after interferon alpha therapy

Cinzia Auriti, Mark W. Kieran, Giovanni Deb, Rita Devito, Luciano Pasquini, Olivier Danhaive

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Interferon-alpha
interferon alfa-2b
Fibroblast Growth Factor 2
Vascular Endothelial Growth Factor A
Myofibroma
Neoplasms
Therapeutics
Heart Atria
Mortality
Congenital Generalized Fibromatosis

Keywords

  • Angiogenesis
  • Basic fibroblast growth factor
  • Interferon alpha-2b
  • Vascular endothelial growth factor
  • Visceral myofibroma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Remission of infantile generalized myofibromatosis after interferon alpha therapy. / Auriti, Cinzia; Kieran, Mark W.; Deb, Giovanni; Devito, Rita; Pasquini, Luciano; Danhaive, Olivier.

In: Journal of Pediatric Hematology/Oncology, Vol. 30, No. 2, 02.2008, p. 179-181.

Research output: Contribution to journalArticle

Auriti, Cinzia ; Kieran, Mark W. ; Deb, Giovanni ; Devito, Rita ; Pasquini, Luciano ; Danhaive, Olivier. / Remission of infantile generalized myofibromatosis after interferon alpha therapy. In: Journal of Pediatric Hematology/Oncology. 2008 ; Vol. 30, No. 2. pp. 179-181.
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