Remission of refractory neurosarcoidosis treated with brain radiotherapy: A case report and a literature review

Micaela Motta, Filippo Alongi, Angelo Bolognesi, Cesare Cozzarini, Nadia Di Muzio, Ferruccio Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcoidosis is a chronic disease of unknown etiology characterized by the presence of T lymphocytes, mononuclear phagocytes, and noncaseating epithelioid granulomas in the tissues. Central nervous system involvement occurs in about 5% of the cases. The chronic form of neurosarcoidosis is particularly resistant to medical treatments. No universally accepted therapeutic protocols are currently available. Corticosteroids are the first line of therapy, but other immunosuppressive treatments are frequently added to the patient's regimen, although this strategy is not adequately supported by controlled clinical trials. For patients resistant to or not tolerating multiple alternate immunotherapeutic drugs, some authors suggest central nervous system radiotherapy. We present a case of a patient with neurosarcoidosis involving the hypothalamo-hypophyseal region and causing panhypopituitarism who had a poor response to and experienced severe side effects from conventional immunosuppressive treatments. The patient experienced a good clinical response to cranial irradiation. We review the literature on this subject.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalNeurologist
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2008

ASJC Scopus subject areas

  • Clinical Neurology

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