TY - JOUR
T1 - Remission of type 2 diabetes after roux-en-y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile
AU - Jiménez, Amanda
AU - Ceriello, Antonio
AU - Casamitjana, Roser
AU - Flores, Lílliam
AU - Viaplana-Masclans, Judith
AU - Vidal, Josep
PY - 2015
Y1 - 2015
N2 - Background: Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associated with altered beta cell function, and relapse of T2DM over time is unknown. Methods: Cross-sectional studies comparing (1) glucose and proinsulin/ insulin response to a standardized liquid mixed meal (SLMM) challenge (n = 31), (2) glucose response in normal living conditions assessed using continuous glucose monitoring (CGM) (n = 16), and prospective observational study comparing (3) rates of relapse of T2DM after surgery (n = 232) in subjects with remission of T2DM ensuing RYGBP or SG. Results: In RYGB individuals, SLMM elicited faster and sharper rise in plasma glucose compared with SG, with 88.2% and 42.9% of the study subjects presenting respectively a peak glucose more than 180 mg/dL (all, P
AB - Background: Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associated with altered beta cell function, and relapse of T2DM over time is unknown. Methods: Cross-sectional studies comparing (1) glucose and proinsulin/ insulin response to a standardized liquid mixed meal (SLMM) challenge (n = 31), (2) glucose response in normal living conditions assessed using continuous glucose monitoring (CGM) (n = 16), and prospective observational study comparing (3) rates of relapse of T2DM after surgery (n = 232) in subjects with remission of T2DM ensuing RYGBP or SG. Results: In RYGB individuals, SLMM elicited faster and sharper rise in plasma glucose compared with SG, with 88.2% and 42.9% of the study subjects presenting respectively a peak glucose more than 180 mg/dL (all, P
KW - Continuous glucose monitoring
KW - Gastric bypass
KW - Glycemic variability
KW - Hypoglycemia
KW - Postprandrial hyperglycemia
KW - Sleeve gastrectomy
KW - Type
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U2 - 10.1097/SLA.0000000000000586
DO - 10.1097/SLA.0000000000000586
M3 - Article
C2 - 25569030
AN - SCOPUS:84925284126
VL - 261
SP - 316
EP - 322
JO - Annals of Surgery
JF - Annals of Surgery
SN - 0003-4932
IS - 2
ER -