Remission of type 2 diabetes after roux-en-y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile

Amanda Jiménez, Antonio Ceriello, Roser Casamitjana, Lílliam Flores, Judith Viaplana-Masclans, Josep Vidal

Research output: Contribution to journalArticle

Abstract

Background: Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associated with altered beta cell function, and relapse of T2DM over time is unknown. Methods: Cross-sectional studies comparing (1) glucose and proinsulin/ insulin response to a standardized liquid mixed meal (SLMM) challenge (n = 31), (2) glucose response in normal living conditions assessed using continuous glucose monitoring (CGM) (n = 16), and prospective observational study comparing (3) rates of relapse of T2DM after surgery (n = 232) in subjects with remission of T2DM ensuing RYGBP or SG. Results: In RYGB individuals, SLMM elicited faster and sharper rise in plasma glucose compared with SG, with 88.2% and 42.9% of the study subjects presenting respectively a peak glucose more than 180 mg/dL (all, P

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalAnnals of Surgery
Volume261
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Continuous glucose monitoring
  • Gastric bypass
  • Glycemic variability
  • Hypoglycemia
  • Postprandrial hyperglycemia
  • Sleeve gastrectomy
  • Type

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

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