Remodelling of sensorimotor maps in paraplegia: A functional magnetic resonance imaging study after a surgical nerve transfer

Daniela Perani, Giorgio A. Brunelli, Marco Tettamanti, Paola Scifo, Franca Tecchio, Paolo M. Rossini, Ferruccio Fazio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The adult mammalian brain has the capacity of reorganising its neural connections in response to lesions/modifications of the peripheral and central nervous system. We show in vivo, using functional magnetic resonance imaging (fMRI), that in paraplegics the lower-limb sensorimotor cortex is invaded by the arm representation. This functional reshaping appears to be reversible. Indeed, surgical transfer of the ulnar nerve to the ipsilateral quadriceps and hip muscles allowed their contraction in a paraplegic patient. During fMRI, these voluntary movements activated the hip and thigh representation in sensorimotor cortex. We suggest that the functional recovery of the lower-limb functional maps might have been driven by the restored somatosensory inputs from the reactivated periphery. The voluntary movements of the lower-limbs are regained through the 're-awakening' of the corresponding sensorimotor cortex.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalNeuroscience Letters
Volume303
Issue number1
DOIs
Publication statusPublished - Apr 27 2001

Fingerprint

Nerve Transfer
Paraplegia
Lower Extremity
Magnetic Resonance Imaging
Hip
Ulnar Nerve
Quadriceps Muscle
Peripheral Nervous System
Thigh
Arm
Central Nervous System
Brain
Sensorimotor Cortex

Keywords

  • Functional magnetic resonance imaging
  • Re-innervation
  • Recovery
  • Sensorimotor maps
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Remodelling of sensorimotor maps in paraplegia : A functional magnetic resonance imaging study after a surgical nerve transfer. / Perani, Daniela; Brunelli, Giorgio A.; Tettamanti, Marco; Scifo, Paola; Tecchio, Franca; Rossini, Paolo M.; Fazio, Ferruccio.

In: Neuroscience Letters, Vol. 303, No. 1, 27.04.2001, p. 62-66.

Research output: Contribution to journalArticle

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