Remote assessment of disease and relapse in major depressive disorder (RADAR-MDD): A multi-centre prospective cohort study protocol

F. Matcham, C. Barattieri Di San Pietro, V. Bulgari, G. De Girolamo, R. Dobson, H. Eriksson, A.A. Folarin, J.M. Haro, M. Kerz, F. Lamers, Q. Li, N.V. Manyakov, D.C. Mohr, I. Myin-Germeys, V. Narayan, P. Bwjh, Y. Ranjan, Z. Rashid, A. Rintala, S. SiddiS.K. Simblett, T. Wykes, M. Hotopf, S. Difrancesco, K. White, A. Ivan, A. Polhemus, J. Ferrao, M. Ringkjøbing-Elema, F. Nobilia, W. Viechtbauer, S. Peelen, J. Boere, N. Cummins, N. Meyer

Research output: Contribution to journalArticle

Abstract

Background: There is a growing body of literature highlighting the role that wearable and mobile remote measurement technology (RMT) can play in measuring symptoms of major depressive disorder (MDD). Outcomes assessment typically relies on self-report, which can be biased by dysfunctional perceptions and current symptom severity. Predictors of depressive relapse include disrupted sleep, reduced sociability, physical activity, changes in mood, prosody and cognitive function, which are all amenable to measurement via RMT. This study aims to: 1) determine the usability, feasibility and acceptability of RMT; 2) improve and refine clinical outcome measurement using RMT to identify current clinical state; 3) determine whether RMT can provide information predictive of depressive relapse and other critical outcomes. Methods: RADAR-MDD is a multi-site prospective cohort study, aiming to recruit 600 participants with a history of depressive disorder across three sites: London, Amsterdam and Barcelona. Participants will be asked to wear a wrist-worn activity tracker and download several apps onto their smartphones. These apps will be used to either collect data passively from existing smartphone sensors, or to deliver questionnaires, cognitive tasks, and speech assessments. The wearable device, smartphone sensors and questionnaires will collect data for up to 2-years about participants' sleep, physical activity, stress, mood, sociability, speech patterns, and cognitive function. The primary outcome of interest is MDD relapse, defined via the Inventory of Depressive Symptomatology-Self-Report questionnaire (IDS-SR) and the World Health Organisation's self-reported Composite International Diagnostic Interview (CIDI-SF). Discussion: This study aims to provide insight into the early predictors of major depressive relapse, measured unobtrusively via RMT. If found to be acceptable to patients and other key stakeholders and able to provide clinically useful information predictive of future deterioration, RMT has potential to change the way in which depression and other long-term conditions are measured and managed. © 2019 The Author(s).
Original languageEnglish
JournalBMC Psychiatry
Volume19
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • M-health
  • Major depressive disorder
  • Observational cohort
  • Outcome measurement
  • Passive sensing
  • Prospective study
  • Remote measurement technology
  • adult
  • anxiety disorder
  • biomedical technology assessment
  • clinical evaluation
  • clinical outcome
  • cognition
  • cohort analysis
  • Composite International Diagnostic Interview score
  • controlled study
  • Depressive Symptomatology Self Report questionnaire score
  • disease course
  • feasibility study
  • human
  • major clinical study
  • major depression
  • medical history
  • mood
  • multicenter study
  • observational study
  • outcome assessment
  • physical activity
  • population research
  • prospective study
  • quality of life
  • remote measurement technology
  • retrospective study
  • Review
  • scoring system
  • sleep quality
  • speech
  • stress
  • World Health Organization
  • adolescent
  • clinical trial
  • female
  • male
  • mobile application
  • procedures
  • questionnaire
  • recurrent disease
  • remote sensing
  • smartphone
  • telemedicine
  • young adult
  • Adolescent
  • Adult
  • Depressive Disorder, Major
  • Female
  • Humans
  • Male
  • Mobile Applications
  • Observational Studies as Topic
  • Prospective Studies
  • Recurrence
  • Remote Sensing Technology
  • Smartphone
  • Surveys and Questionnaires
  • Telemedicine
  • Young Adult

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    Matcham, F., Barattieri Di San Pietro, C., Bulgari, V., De Girolamo, G., Dobson, R., Eriksson, H., Folarin, A. A., Haro, J. M., Kerz, M., Lamers, F., Li, Q., Manyakov, N. V., Mohr, D. C., Myin-Germeys, I., Narayan, V., Bwjh, P., Ranjan, Y., Rashid, Z., Rintala, A., ... Meyer, N. (2019). Remote assessment of disease and relapse in major depressive disorder (RADAR-MDD): A multi-centre prospective cohort study protocol. BMC Psychiatry, 19(1). https://doi.org/10.1186/s12888-019-2049-z