Removal of white cells from red cells by transfusion through a new filter

G. Sirchia, B. Wenz, P. Rebulla, A. Parravicini, V. Carnelli, F. Bertolini

Research output: Contribution to journalArticle

Abstract

The effectiveness of a new filter (RC100) for the preparation of white cell-depleted red cells (RBCs) at the bedside was evaluated in vitro and in vivo using three RBC products: standard RBC concentrate (CPDA units), RBCs suspended in saline-adenine-glucose-mannitol additive solution after the removal of plasma (SAGM units), and RBCs suspended in SAGM after the removal of plasma and buffy coat (SAGM-BC units). Median RBC recovery was at least 92 percent when 2 units were administered through one filter; median values for residual white cells and platelets were ≤20 x 106 and ≤2.5 x 109 per 2 units, respectively. The in vivo study was carried out in 80 multiply transfused patients with thalassemia, 35 of whom had experienced frequent nonhemolytic transfusion reactions when given standard or buffy coat-free RBCs. During the 6-month study, each patient was given two transfusions of each type of RBC product. One febrile nonhemolytic transfusion reaction occurred in each of two patients receiving SAGM-BC units, but in no other case. If the flow rate is not reduced, the median transfusion time is 35 minutes per CPDA unit and 15 minutes per SAGM and SAGM-BC unit. It is concluded that the transfusion of RBCs through the RC100 is a simple and effective procedure to administer white cell-depleted RBCs prepared at the bedside.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalTransfusion
Volume30
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Hematology

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    Sirchia, G., Wenz, B., Rebulla, P., Parravicini, A., Carnelli, V., & Bertolini, F. (1990). Removal of white cells from red cells by transfusion through a new filter. Transfusion, 30(1), 30-33.