An approach to evaluating the genetic components of essential hypertension using an animal model, the Milan hypertensive strain (MHS) of rats, and studies in human families with positive and negative histories for high blood pressure are described and discussed. Differences at renal and cellular levels between MHS and its normotensive control strain. MNS, show mane similarities to those between offspring from hyper- and normotensive families in humans. These include. with respect to the former group of each species. lower erythrocyte volume and Na content, higher Na-K cotransport across red blood cell (RBC) membranes higher Na excretion after load, and greater pressor effect in transplanted kidneys. A novel protein found in rat RRC cytoskeleton appears to have a function in Na-K cotransport and it may, eventually. he possible to demonstrate in man.
|Journal||Journal of Cardiovascular Pharmacology|
|Publication status||Published - 1988|
- Animal model
- Essential hypertension
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine