STUDI DI TOSSICITA' EPATICA E RENALE NEL TOPO DOPO SOMMINISTRAZIONE DI SACCARINA SODICA: INTERRUZIONI NELLA MONOELICA DEL DNA

Translated title of the contribution: Renal and hepatic toxicity studies in mice treated with sodium saccharin: Single-stranded DNA breaks

C. F. Cesarone, C. Bolognesi, L. Santi

Research output: Contribution to journalArticle

Abstract

The renal and hepatic effects of in vivo treatment with saccharin have been determined as increased DNA elutability on filter. A direct dose-damage relationship was not observed in the kidney or in the liver DNA of treated mice. Doses of 50, 100 and 200 mg/kg seem to induce in almost all the experiments the same level of single-stranded breaks. The DNA elutability is increased in the range 130- 210%, compared with controls.

Translated title of the contributionRenal and hepatic toxicity studies in mice treated with sodium saccharin: Single-stranded DNA breaks
Original languageItalian
Pages (from-to)2486-2491
Number of pages6
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume56
Issue number23
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Medicine(all)

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