The renal and hepatic effects of in vivo treatment with saccharin have been determined as increased DNA elutability on filter. A direct dose-damage relationship was not observed in the kidney or in the liver DNA of treated mice. Doses of 50, 100 and 200 mg/kg seem to induce in almost all the experiments the same level of single-stranded breaks. The DNA elutability is increased in the range 130- 210%, compared with controls.
|Translated title of the contribution||Renal and hepatic toxicity studies in mice treated with sodium saccharin: Single-stranded DNA breaks|
|Number of pages||6|
|Journal||Bollettino della Societa Italiana di Biologia Sperimentale|
|Publication status||Published - 1980|
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