Abstract
Aim: Data on left ventricular hypertrophy (LVH) in patients with renal artery stenosis (RAS) and its regression following renal revascularization are scanty. We performed a meta-analysis to provide comprehensive information on this clinically relevant issue. Methods: Full articles providing data on: LVH, as assessed by echocardiography, in RAS patients as compared with essential hypertensive counterparts; changes of left ventricular (LV) mass index after renal artery revascularization were considered. Results: A total of 905 study participants (RAS=446, essential hypertensive=459) of both sex were included in nine studies. Pooled LV mass index was higher in RAS than in essential hypertensive patients (140.4±11.1g/m 2 versus 121.8±6.2g/m 2, standard mean difference being 0.41±0.07 [95% confidence interval (CI) 0.27-0.51, P<0.001]. Among 360 RAS patients undergone renal revascularization from eight studies, baseline and post-intervention pooled mean LV mass index values were 129.0±10.2g/m 2 and 115.5±9.9g/m 2, respectively, the standard mean difference being-0.36±0.06 (95% CI from -0.47 to -0.25, P<0.001). These findings were unaffected by publication bias or single study effect. Conclusion: Our meta-analysis indicates that RAS patients have an increased likelihood of LVH compared with essential hypertensive counterparts and renal artery revascularization has a beneficial effect on LV structure, as reflected by a significant decrease in LV mass index.
| Original language | English |
|---|---|
| Pages (from-to) | 2339-2345 |
| Number of pages | 7 |
| Journal | Journal of Hypertension |
| Volume | 35 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2017 |
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Keywords
- hypertension
- left ventricular hypertrophy
- renal artery stenosis
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Renal artery stenosis and left ventricular hypertrophy : An updated review and meta-analysis of echocardiographic studies. / Cuspidi, Cesare; Dell'Oro, Raffaella; Sala, Carla; Tadic, Marijana; Gherbesi, Elisa; Grassi, Guido; Mancia, Giuseppe.
In: Journal of Hypertension, Vol. 35, No. 12, 01.12.2017, p. 2339-2345.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Renal artery stenosis and left ventricular hypertrophy
T2 - An updated review and meta-analysis of echocardiographic studies
AU - Cuspidi, Cesare
AU - Dell'Oro, Raffaella
AU - Sala, Carla
AU - Tadic, Marijana
AU - Gherbesi, Elisa
AU - Grassi, Guido
AU - Mancia, Giuseppe
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Aim: Data on left ventricular hypertrophy (LVH) in patients with renal artery stenosis (RAS) and its regression following renal revascularization are scanty. We performed a meta-analysis to provide comprehensive information on this clinically relevant issue. Methods: Full articles providing data on: LVH, as assessed by echocardiography, in RAS patients as compared with essential hypertensive counterparts; changes of left ventricular (LV) mass index after renal artery revascularization were considered. Results: A total of 905 study participants (RAS=446, essential hypertensive=459) of both sex were included in nine studies. Pooled LV mass index was higher in RAS than in essential hypertensive patients (140.4±11.1g/m 2 versus 121.8±6.2g/m 2, standard mean difference being 0.41±0.07 [95% confidence interval (CI) 0.27-0.51, P<0.001]. Among 360 RAS patients undergone renal revascularization from eight studies, baseline and post-intervention pooled mean LV mass index values were 129.0±10.2g/m 2 and 115.5±9.9g/m 2, respectively, the standard mean difference being-0.36±0.06 (95% CI from -0.47 to -0.25, P<0.001). These findings were unaffected by publication bias or single study effect. Conclusion: Our meta-analysis indicates that RAS patients have an increased likelihood of LVH compared with essential hypertensive counterparts and renal artery revascularization has a beneficial effect on LV structure, as reflected by a significant decrease in LV mass index.
AB - Aim: Data on left ventricular hypertrophy (LVH) in patients with renal artery stenosis (RAS) and its regression following renal revascularization are scanty. We performed a meta-analysis to provide comprehensive information on this clinically relevant issue. Methods: Full articles providing data on: LVH, as assessed by echocardiography, in RAS patients as compared with essential hypertensive counterparts; changes of left ventricular (LV) mass index after renal artery revascularization were considered. Results: A total of 905 study participants (RAS=446, essential hypertensive=459) of both sex were included in nine studies. Pooled LV mass index was higher in RAS than in essential hypertensive patients (140.4±11.1g/m 2 versus 121.8±6.2g/m 2, standard mean difference being 0.41±0.07 [95% confidence interval (CI) 0.27-0.51, P<0.001]. Among 360 RAS patients undergone renal revascularization from eight studies, baseline and post-intervention pooled mean LV mass index values were 129.0±10.2g/m 2 and 115.5±9.9g/m 2, respectively, the standard mean difference being-0.36±0.06 (95% CI from -0.47 to -0.25, P<0.001). These findings were unaffected by publication bias or single study effect. Conclusion: Our meta-analysis indicates that RAS patients have an increased likelihood of LVH compared with essential hypertensive counterparts and renal artery revascularization has a beneficial effect on LV structure, as reflected by a significant decrease in LV mass index.
KW - hypertension
KW - left ventricular hypertrophy
KW - renal artery stenosis
UR - http://www.scopus.com/inward/record.url?scp=85033790005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033790005&partnerID=8YFLogxK
U2 - 10.1097/HJH.0000000000001500
DO - 10.1097/HJH.0000000000001500
M3 - Review article
AN - SCOPUS:85033790005
VL - 35
SP - 2339
EP - 2345
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 12
ER -