Renal aspects of the hypertension optimal treatment (HOT) study

Luis M. Ruilope, Lennart Hansson, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review


The Hypertension Optimal Treatment (HOT) Study is a prospective, randomized, multicenter trial currently progress in 26 countries. Altogether 19,193 patients have been recruited. The two main aims are to evaluate the relationship between target levels of diastolic blood pressure (≤90, ≤85 or ≤80 mmHg) and the incidence of cardiovascular morbidity and mortality in hypertensive patients, and the effects on morbidity and mortality of a low dose of acetylsalicylic acid (75 mg ASA) compared with placebo. Serum creatinine will be measured in every patient initially and at the end of the study. Creatinine clearance will be determined following the Cockroft-Gault formula. As a secondary objective, the HOT Study will seek to answer two questions: 1) does decreased renal function predict a worse control of blood pressure? 2) does a lower diastolic blood pressure goal improve the renal prognosis in essential hypertension. This paper sets out the initial evaluation of renal function and the relationship with control of blood pressure after the first 12 months of follow-up. The answer to the first question appears to be negative: lower renal function does not predict worse control of blood pressure. However, in patients with lower renal function more intensive treatment may be needed to attain the diastolic blood pressure target.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of Nephrology
Issue number3
Publication statusPublished - May 1996


  • Antihypertensive therapy
  • Blood pressure control
  • Calcium antagonists
  • Creatinine clearance
  • HOT Study
  • Renal function

ASJC Scopus subject areas

  • Nephrology


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