Abstract
The recent introduction of new antiretroviral drugs, characterized by high efficiency and improved safety profiles, has not reduced the incidence of long-term adverse effects, in some cases manifested as selective organ damage. The presence of organ damage in patients receiving antiretroviral treatment is not only the expression of treatment toxicity, but also a complex interaction between individual risk factors, HIV-correlated effects, and antiretroviral drug toxicity. Kidney damage belongs to these adverse events. Renal function abnormalities are present in a large percentage of patients with HIV infection. Moreover, HIV-associated renal disease seems to be associated with progression to AIDS and death. In this review we address the various aspects of the epidemiology of renal damage, the interaction and the convergent effect of HIV and antiretroviral drugs in the onset of kidney injury, the interplay between kidney function and other organ systems, early clinical management, the monitoring of renal function, and a proposal of clinical approach to kidney disease in daily practice. Finally, we discuss future perspectives of renal damage in HIV patients and evaluate the patient's perspective.
| Original language | English |
|---|---|
| Pages (from-to) | 37-53 |
| Number of pages | 17 |
| Journal | AIDS Reviews |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - Jan 2012 |
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Keywords
- Antiretroviral therapy
- HIV
- Kidney
- Renal disease
- Tenofovir
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)
Cite this
Renal complications in HIV disease : Between present and future. / Maggi, Paolo; Bartolozzi, Dario; Bonfanti, Paolo; Calza, Leonardo; Cherubini, Chiara; Di Biagio, Antonio; Marcotullio, Simone; Montella, Francesco; Montinaro, Vincenzo; Mussini, Cristina; Narciso, Pasquale; Rusconi, Stefano; Vescini, Fabio.
In: AIDS Reviews, Vol. 14, No. 1, 01.2012, p. 37-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Renal complications in HIV disease
T2 - Between present and future
AU - Maggi, Paolo
AU - Bartolozzi, Dario
AU - Bonfanti, Paolo
AU - Calza, Leonardo
AU - Cherubini, Chiara
AU - Di Biagio, Antonio
AU - Marcotullio, Simone
AU - Montella, Francesco
AU - Montinaro, Vincenzo
AU - Mussini, Cristina
AU - Narciso, Pasquale
AU - Rusconi, Stefano
AU - Vescini, Fabio
PY - 2012/1
Y1 - 2012/1
N2 - The recent introduction of new antiretroviral drugs, characterized by high efficiency and improved safety profiles, has not reduced the incidence of long-term adverse effects, in some cases manifested as selective organ damage. The presence of organ damage in patients receiving antiretroviral treatment is not only the expression of treatment toxicity, but also a complex interaction between individual risk factors, HIV-correlated effects, and antiretroviral drug toxicity. Kidney damage belongs to these adverse events. Renal function abnormalities are present in a large percentage of patients with HIV infection. Moreover, HIV-associated renal disease seems to be associated with progression to AIDS and death. In this review we address the various aspects of the epidemiology of renal damage, the interaction and the convergent effect of HIV and antiretroviral drugs in the onset of kidney injury, the interplay between kidney function and other organ systems, early clinical management, the monitoring of renal function, and a proposal of clinical approach to kidney disease in daily practice. Finally, we discuss future perspectives of renal damage in HIV patients and evaluate the patient's perspective.
AB - The recent introduction of new antiretroviral drugs, characterized by high efficiency and improved safety profiles, has not reduced the incidence of long-term adverse effects, in some cases manifested as selective organ damage. The presence of organ damage in patients receiving antiretroviral treatment is not only the expression of treatment toxicity, but also a complex interaction between individual risk factors, HIV-correlated effects, and antiretroviral drug toxicity. Kidney damage belongs to these adverse events. Renal function abnormalities are present in a large percentage of patients with HIV infection. Moreover, HIV-associated renal disease seems to be associated with progression to AIDS and death. In this review we address the various aspects of the epidemiology of renal damage, the interaction and the convergent effect of HIV and antiretroviral drugs in the onset of kidney injury, the interplay between kidney function and other organ systems, early clinical management, the monitoring of renal function, and a proposal of clinical approach to kidney disease in daily practice. Finally, we discuss future perspectives of renal damage in HIV patients and evaluate the patient's perspective.
KW - Antiretroviral therapy
KW - HIV
KW - Kidney
KW - Renal disease
KW - Tenofovir
UR - http://www.scopus.com/inward/record.url?scp=84858991455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858991455&partnerID=8YFLogxK
M3 - Article
C2 - 22297503
AN - SCOPUS:84858991455
VL - 14
SP - 37
EP - 53
JO - AIDS Reviews
JF - AIDS Reviews
SN - 1139-6121
IS - 1
ER -